Correlation of Typical LBBB Mechanical Activation Pattern by 2D Strain Echocardiography With Acute GWE Improvement in Patients Receiving LBBp or Conventional BiVp for Cardiac Resynchronization Therapy (Echo LBBp)
Recruiting · NCT06689111 · Interventional (participants receive a specific treatment) · Lead sponsor: University Hospital of Patras
View the official record on ClinicalTrials.gov →Interventions studied
CRT with the standard method through csLeft bundle branch pacing lead
What this trial is about
The present study is a multicenter interventional non randomised study in patients requiring an implantable device for cardiac resynchronization therapy. Its primary objective is to investigate whether the presence of a specific echocardiographic contraction pattern before implantation is associated with increased rates of acute improvement in myocardial function (as measured by an ultrasound) and to compare the improvement in two groups of patients based on the type of pacing (biventricular or left-sided pacing)
Who can take part
Age range
18 Years to 90 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- \>18 years \< 90 years
- Patients with a documented indication for resynchronization therapy \[symptomatic patients despite optimal medication, HFrEF (EF\<35%), LBBB QRS morphology\]
- COMPLETE LBBB (LBBB defined as QRS\>130msec, wide "notched or slurred" R wave in leads I, aVL, V5, V6 and occasional RS pattern in V5, V6, absence of Q waves in leads I, V5 and V6 but in lead aVL narrow Q wave may be present in the absence of myocardial pathology, R peak time \>60ms in leads V5 and V6 but normal in leads V1, V2, V3 when small R's are discernible in precardial leads, ST and T usually opposite to QRS direction)
- Patients with ntraventricular septum diameter \>8 mm
- Written informed consent
Exclusion criteria
- Patients with RBBB or atypical LBBB QRS morphology
- Patients eligible for an upgrade procedure (already carring a PM or ICD)
- Patients with hypertrophic cardiomyopathy
Where it is running
1 location listed.
- University Hospital of Patras - Pátrai, Greece, Greece