A Comparison Study of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING
Recruiting · NCT06712628 · Observational (researchers observe without assigning treatment) · Lead sponsor: AbbVie
View the official record on ClinicalTrials.gov →What this trial is about
This study will compare the retention rates for UPA vs. TNFi treatment in adult participants with moderate to severe active RA per local label and according to local standard of care This is a mono-country, prospective, multi-center observational study in patients with moderate to severe active RA receiving UPA or TNFi therapy. Around 678 participants will be enrolled in approximately 80 sites in Germany. Study recruitment will last approximately 24 months, and the study participation time will be up to 24 months, for a total study duration of approximately 48 months.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Current or Past participants with a confirmed diagnosis of moderate to severe active RA upon judgement of the treating physician.
- Physician decision on participant treatment with Upadacitinib (UPA) or tumor necrosis factor inhibitor (TNFi) must have been reached prior to and independently of recruitment in the study
- UPA or TNFi prescribed in accordance with the applicable approved label and local regulatory and reimbursement policies
Exclusion criteria
- Participation in a clinical trial with an investigational drug (within a minimum of 30 days or 5 half-lives of the investigational drug \[whichever is longer\] prior to baseline)
- Prior treatment with Upadacitinib
- Prior treatment with the same tumor necrosis factor inhibitor as the one prescribed for this study
Where it is running
60 locations listed.
- MVZ Weserbergland /ID# 276009 - Bad Pyrmont, Germany
- Rheumapraxis Steglitz /ID# 280323 - Berlin, Germany
- Private Practice - Dr. Silke Zinke /ID# 276366 - Berlin, Germany
- MVZ Herzogin Elisabeth Hospital /ID# 272725 - Braunschweig, Germany
- Private Practice - Dr. Sebastian Schuh /ID# 272731 - Coburg, Germany
- MVZ-Medizinisches Versorgungszentrum Daun GmbH /ID# 285725 - Daun, Germany
- Rheumapraxis Düren /ID# 272726 - Düren, Germany
- Praxis Dilltal /ID# 272727 - Ehringshausen, Germany
- Private Practice - Dr. Daniel Bestler /ID# 272741 - Erfurt, Germany
- Praxis Fiene /ID# 279410 - Greifswald, Germany
- Private Practice - Dr. Hauke E. Heintz /ID# 278081 - Hamburg, Germany
- Rheumapraxis Kaufering /ID# 283852 - Kaufering, Germany
- Prof-med-stud.de /ID# 285869 - Munich, Germany
- Die Fachaerzte im Rottal - Nephrologie, Rheumatologie /ID# 284221 - Pfarrkirchen, Germany
- Praxis F. Schattenberg /ID# 280322 - Waren, Germany
- Cellitinnen-Krankenhaus St. Josef /ID# 275926 - Wuppertal, Germany
- Praxis Barmen /ID# 277514 - Wuppertal, Germany
- Gemeinschaftspraxis Innere Medizin/Rheumatologie /ID# 278584 - Freiburg im Breisgau, Baden-Wurttemberg, Germany
- Rheumapraxis Heidelberg /ID# 276475 - Heidelberg, Baden-Wurttemberg, Germany
- Rheumapraxis Haas Tubingen /ID# 275536 - Tübingen, Baden-Wurttemberg, Germany
- Rheumapraxis Ulm Dr. med. Nadia Rinaldi /ID# 276293 - Ulm, Baden-Wurttemberg, Germany
- Dr. Med. Thomas Marycz /ID# 274646 - Amberg, Bavaria, Germany
- Rheumapraxis Am Webereck /ID# 274412 - Augsburg, Bavaria, Germany
- Dr. Harmuth /ID# 273401 - Marktredwitz, Bavaria, Germany
- Praxiszentrum Dr. Med. Klaus Kruger Dres. Günther Kellerer Und Paul Kellerer /ID# 276138 - Munich, Bavaria, Germany
- Klinische Forschung Im Medizinischen Versorgungalltag Gbr /ID# 274587 - Planegg, Bavaria, Germany
- Medikomp Mvz /ID# 285898 - Elsterwerda, Brandenburg, Germany
- Private Practice - Dr. Dirk Wernicke /ID# 276820 - Hohen Neuendorf, Brandenburg, Germany
- Praxis K. Pagel /ID# 279121 - Hoppegarten, Brandenburg, Germany
- Rheumahaus Studien GbR /ID# 275917 - Potsdam, Brandenburg, Germany
- Rheumatologisch Immunologisch /ID# 275830 - Templin, Brandenburg, Germany
- Rheumatism Center Mittelhessen /ID# 274641 - Bad Endenbach, Hesse, Germany
- Deutsches Endokrinologisches Versorgungszentrum DEVZ - MVZ GdR /ID# 274291 - Frankfurt am Main, Hesse, Germany
- Mvz Dr. Med. Mahdy and Kollegen - Braunschweig /ID# 284988 - Braunschweig, Lower Saxony, Germany
- Stadtisches Klinikum Braunschweig /ID# 282626 - Braunschweig, Lower Saxony, Germany
- Private Practice - Dr. Jorg Sensse /ID# 281907 - Gifhorn, Lower Saxony, Germany
- Rheumatologische Facharztpraxis /ID# 286591 - Hanover, Lower Saxony, Germany
- Rheumapraxis Hannover-List /ID# 273735 - Hanover, Lower Saxony, Germany
- Praxis. F. Bigdeli-Wilshusen /ID# 273455 - Hanover, Lower Saxony, Germany
- Rheumatologie Kassel /ID# 275916 - Kassel, Lower Saxony, Germany
- Rheumapraxis An Der Hase /ID# 276949 - Osnabrück, Lower Saxony, Germany
- Fachpraxis fur Rheumatologie und Osteologie /ID# 275359 - Weyhe, Lower Saxony, Germany
- Dr. Ann-Dorthe Holst /ID# 285741 - Ludwigslust, Mecklenburg-Vorpommern, Germany
- Private Practice - Dr. Thilo Klopsch - Stargarder Strasse /ID# 276367 - Neubrandenburg, Mecklenburg-Vorpommern, Germany
- Rheumatologische Facharztpraxis - Schwerin /ID# 284785 - Schwerin, Mecklenburg-Vorpommern, Germany
- Klinikum Bielefeld Rosenhohe /ID# 283715 - Bielefeld, North Rhine-Westphalia, Germany
- Rheumatology Euskirchen /ID# 285419 - Euskirchen, North Rhine-Westphalia, Germany
- Rheumazentrum Ruhrgebiet /ID# 275518 - Herne, North Rhine-Westphalia, Germany
- St.Elisabeth Hospital Meerbusch /ID# 275030 - Meerbusch, North Rhine-Westphalia, Germany
- Gesundheitscampus Monheim /ID# 283726 - Monheim am Rhein, North Rhine-Westphalia, Germany
- Rheumazentrum Ratingen /ID# 275707 - Ratingen, North Rhine-Westphalia, Germany
- Praxis Dr. med. Florian Beyer /ID# 274293 - Kaiserslautern, Rhineland-Palatinate, Germany
- Private Practice - Dr. Alexander Lautwein /ID# 282328 - Wittlich, Rhineland-Palatinate, Germany
- Rheumapraxis Zweibruecken - Matar /ID# 282656 - Zweibrücken, Rhineland-Palatinate, Germany
- Rheumapraxis am Schlossberg /ID# 272728 - Homburg, Saarland, Germany
- Dr. Murawski /ID# 272724 - Neunkirchen, Saarland, Germany
- Knappschaftsklinikum Saar /ID# 279852 - Püttlingen, Saarland, Germany
- Rheumapraxis Dr. Prothmann /ID# 279851 - Püttlingen, Saarland, Germany
- Medizinischen Versorgungszentrums Agilomed /ID# 274887 - Chemnitz, Saxony, Germany
- Schwerpunktpraxis Rheumatologie und Klinische Immunologie /ID# 282628 - Dresden, Saxony, Germany
Showing 60 of 72 listed sites. See the official record for the complete list.
Read the full protocol, contacts and eligibility on ClinicalTrials.gov →