Transcranial Pulse Stimulation. a Potential Treatment for Early Dementia
Recruiting · NCT06730438 · Interventional (participants receive a specific treatment) · Lead sponsor: Francesca Pistoia
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Alzheimer's Disease (AD) is characterized by the absence of treatments to slow, stop, or reverse its course, with patients finally losing cognitive functions, skills and independence. It is a chronic degenerative disease with high social and medical burden worldwide: AD ranked third among neurological disorders in terms of disability-adjusted life years (DALY) rates. The primary aim of the research protocol is to improve care for patients with AD, by implementing, with an innovative method, the currently available repertoire of neuromodulation techniques. For this aim, we will investigate whether Transcranial Pulse Stimulation (TPS) may induce cognitive improvement in patients with an early stage of dementia.
Who can take part
Inclusion criteria
- age\>18 years
- diagnosis of early dementia according to current international guidelines
- disease duration of at least 12 months
- consent to participate in the study.
Exclusion criteria
- medical instability interfering with standard neurological assessment
- any contraindication to preliminary MRI for MR-based real-time neuronavigation
- comorbidities which may interfere with cognitive status
- any contraindication to Transcranial Pulse Stimulation.
Where it is running
2 locations listed.
- San Salvatore Hospital - L’Aquila, Italy, Italy
- San Salvatore Hospital - L’Aquila, Italy, Italy