Ketogenic Diets for Weight Loss Maintenance: Impact on Energy Expenditure and Appetite in Individuals With Obesity
Recruiting · NCT06736028 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Alabama at Birmingham
View the official record on ClinicalTrials.gov →Interventions studied
Behavioral SupportCalorie RestrictionDiet Therapy
What this trial is about
The goal of this clinical trial is to investigate whether a Ketogenic Diet (KD) can increase Total Energy Expenditure (TEE), while benefiting appetite, during weight loss maintenance in reduced-obese individuals.
Who can take part
Age range
18 Years to 65 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- BMI 30-45 kg/m2
- Both men and women
- Age between 18-65 years
- Sedentary to moderately active (\<2 h/wk of moderate, structured, intentional, exercise)
Exclusion criteria
- Pregnancy or lactation
- Daily use of tobacco (\>1 pk/wk)
- Change in weight greater than 5 lb in the previous 3 months
- Cognitive impairment
- Previous bariatric surgery
- History of eating disorder
- Presence of any condition (e.g. DM2, PCOS, inflammatory disease, untreated thyroid disease, fluid overload states such as chronic kidney disease, congestive heart failure, or cirrhosis)
- Use of any medication (e.g., glucocorticoid, GLP-1 analogues, hormone replacement therapy) deemed to interfere with study outcomes.
- Pre-menopausal women will need to have a regular menstrual cycle (28+/-2 days) or be on hormonal contraceptives
- Fasting glucose plasma concentration \>125 mg/dl and/or HbA1c \> 6.4%
Where it is running
1 location listed across 1 US state.
- University of Alabama at Birmingham - Birmingham, Alabama, United States