Total-body Glucose Utilization in Obesity
Recruiting · NCT06739473 · Interventional (participants receive a specific treatment) · Lead sponsor: Turku University Hospital
View the official record on ClinicalTrials.gov →Interventions studied
CEUS or Contrast enhanced UltrasoundColdH2[15O]O PET/CTHyperinsulinemic euglycemic clampMovies[18F]FDG PET/CT
What this trial is about
There are three goals for this study. One is to investigate how different emotions and exposure to cold affect blood flow in the body. The second aim is to study how insulin affects blood flow and tissue glucose uptake, and to study whether this effect is altered in obesity. Last, the study focuses on establishing the lowest dose of a PET radiotracer, oxygen-15 labelled water, that can be used in clinical studies with a new whole-body PET scanner.
Who can take part
Age range
20 Years to 60 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Phase 4
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age 20-60 years
- BMI either 18.5-25 kg/m2 or above 30 kg/m2
- Use of hormonal contraception for women in child bearing age
Exclusion criteria
- In the lean group history of obesity or type 2 diabetes
- In the group with obesity: current or previous use of GLP-1-agonists or insulin
- History of eating disorders
- Smoking, use of narcotics, excessive use of alcohol
- Previous participation in PET studies
- Previous significant exposure to radiation
- Claustrophobia
- Active plans for concieving (both sexes)
- Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
Where it is running
1 location listed.
- Turku PET Centre - Turku, Finland