The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population
Recruiting · NCT06755372 · Observational (researchers observe without assigning treatment) · Lead sponsor: Ain Shams University
View the official record on ClinicalTrials.gov →What this trial is about
Chronic kidney disease (CKD) is a significant public health issue in Egypt, leading to end-stage renal disease (ESRD). ESRD patients often suffer from oral abnormalities due to the disease and medications. Periodontitis is linked to systemic diseases, including renal disease, with inflammation playing a key role. TLR4 genetic variations may influence susceptibility to CKD and periodontitis. This study investigates the association between TLR4 \[Gly/Thr (rs2149356)\] polymorphism and chronic periodontal disease in ESRD patients in Egypt.
Who can take part
Age range
30 Years to 60 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Age: 30 to 60 years
- Gender: Both male and female
- Diagnosed with Periodontitis stage II and/or stage III
- Systemically healthy, no history of systemic diseases
- Not on long-term medications
Exclusion criteria
- Smokers
- Individuals with any systemic disease or long-term medication use
- Group II: ESRD Patients with Periodontitis
- Inclusion Criteria:
- Age: 30 to 60 years
- Gender: Both male and female
- Diagnosed with end-stage renal disease (ESRD) on regular hemodialysis
- Diagnosed with Periodontitis stage II and/or stage III
- Unrelated Egyptians from a similar socioeconomic status, residing in the same geographical area
- Underlying type 2 diabetes mellitus
- Exclusion Criteria:
- Individuals with kidney transplants
- Individuals with systemic diseases other than diabetes
- History of malignancy
- Smokers
Where it is running
1 location listed.
- hemodialysis center at Benha University Hospital. - Al Fayyum, Faiyum Governorate, Egypt