The Role of Epicardial Adiposity in Heart Failure With Preserved Ejection Fraction
Recruiting · NCT06768437 · Observational (researchers observe without assigning treatment) · Lead sponsor: University of Leicester
View the official record on ClinicalTrials.gov →What this trial is about
In this study the investigators are aiming to recruit 130 patients with heart failure with preserved ejection fraction who are obese and non-obese to undergo CT and MRI scans, as well as some other investigations including blood tests, to help investigate if having more fat around the heart leads to worse heart function in this condition. This may lead to the development of new treatments aimed at lowering fat levels around the heart and in the rest of the body, specifically to treat HFpEF.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Participant is willing and able to give informed consent for participation in the study.
- Aged ≥18 years old
- Diagnosed with HFpEF by an experienced cardiologist or signs and symptoms of heart failure with a HFA-PEFF score ≥5
- Able to understand written English
Exclusion criteria
- LV ejection fraction \<45%
- Recovered ejection fraction (previous ejection fraction \<40%) unless reduced ejection fraction was in context of tachycardia induced cardiomyopathy (eg atrial fibrillation/atrial flutter)
- Severe primary valvular heart disease
- HFpEF due to infiltrative cardiomyopathy (cardiac amyloidosis or sarcoidosis), genetic hypertrophic cardiomyopathy, restrictive cardiomyopathy/pericardial disease or congenital heart disease
- Known heritable, idiopathic or drug-induced pulmonary arterial hypertension
- Absolute contraindications to cardiac CT or MRI including estimated glomerular filtration rate (eGFR) ≤30ml/min/1.73m2. Patients with MRI-compatible devices are be excluded.
- Women who are pregnant
Where it is running
1 location listed.
- Glenfield Hospital, University Hospitals of Leicester - Leicester, Leicestershire, United Kingdom