Association Between GalectiN-3 and POSt-operative AtrIal Fibrillation After Coronary Artery BypaSs Graft
Recruiting · NCT06768528 · Observational (researchers observe without assigning treatment) · Lead sponsor: University of Sao Paulo General Hospital
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The goal of this observational study is to test the association between high levels of Galectin-3 and the occurrence of post-operative atrial fibrillation after isolated coronary artery bypass grafting (CABG). The main question\[s\] it aims to answer are: * Is Galectin-3 an accurate biomarker to predict higher risk of developing post-operative atrial fibrillation? * Are high levels of Galectin-3 associated to other post-operative complications and major adverse cardiovascular events? Participants will be enrolled during pre-operative evaluation and a peripheral blood sample collection will be performed in the 24h before CABG. Participants will then be followed for a period of 12 months (daily during hospitalization and 3 appointments after hospital discharge) to determine whether patients with higher levels of Galectin-3 will have worse outcomes.
Who can take part
Inclusion criteria
- Patients undergoing coronary artery bypass graft surgery
Exclusion criteria
- Inability to sign the free and informed consent form
- Renal dysfunction with estimated glomerular filtration rate less than 30ml / min / 1.73m² or dialysis therapy
- Moderate to severe left ventricular dysfunction (ejection fraction \< 40%)
- Patients with previous atrial fibrillation
- Pregnancy
- Concomitant valve surgery
Where it is running
1 location listed.
- Instituto do Coração - Hospital das Clínicas - Faculdade de Medicina da Universidade de São Paulo - São Paulo, São Paulo, Brazil