New Mechanisms of Obesity
Recruiting · NCT06768827 · Interventional (participants receive a specific treatment)
View the official record on ClinicalTrials.gov →Interventions studied
Lactulose Oral Product
What this trial is about
Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition. Herein, investigators propose to elucidate the interaction between colonic fermentation and insulin resistance in modulating metabolism in youth with obesity.
Who can take part
Age range
15 Years to 22 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age 15 to 22 years
- In puberty (girls and boys: Tanner stage III-V);
- BMI \>85th
Exclusion criteria
- Pregnancy;
- endocrinopathies (e.g., Cushing syndrome);
- substance abuse;
- medications affecting insulin resistance such as metformin, GLP-1 analogues; -
- high fibers intake (\> 30g/day) as assessed by a 3-day food record.
Where it is running
1 location listed across 1 US state.
- Yale University - New Haven, Connecticut, United States