Autophagy/Apoptosis Balance in Placental Vascular Pathologies
Recruiting · NCT06779916 · Observational (researchers observe without assigning treatment) · Lead sponsor: Centre Hospitalier Universitaire de Nīmes
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Pregnancy increases the risk of thrombosis. Placenta-mediated diseases are a risk factor for cardiovascular pathologies and can lead to maternal-fetal morbidity and mortality. It is essential to understand the cellular and molecular mechanisms of dysfunctions at the vascular-placental interface so that systemic vascular risk can be characterized and, ultimately, screened for, on the basis of new markers (targeted preventive management). Deregulated autophagy could be the starting point for cell death by apoptosis or necrosis leading to complications. The pathophysiological mechanisms involved in trophoblast apoptosis are incompletely described. This project follows on from the GrossAuTop-1 study, which investigated the intra- and inter-individual variability of autophagy and apoptosis activities in women during pregnancy. The aim of this project is to study autophagy and apoptosis activities specifically in women developing a placental vascular complication during pregnancy.
Who can take part
Inclusion criteria
- Pregnant women developing a placental vascular complication (preeclampsia and/or intrauterine growth retardation), hospitalized and delivering at Nimes University Hospital.
- Pregnant woman with free and informed consent.
- Pregnant woman affiliated with and/or benefiting from a health insurance scheme.
Exclusion criteria
- Multiple pregnancy.
- Presence of hypertension and/or proteinuria prior to pregnancy.
- Participant in an interventional drug study.
- Persons in a period of exclusion determined by another study.
- Persons under court protection, guardianship or curatorship.
- Persons unable to give consent.
- Persons for whom it is impossible to give informed information.
Where it is running
1 location listed.
- Nimes University Hospital - Nîmes, France