Anxiety During Abstinence in AUD

Inclusion criteria

• Participants with Alcohol use Disorder):
• Between the ages of 21 and 55
• Right-handed
• Able to perform informed consent and comply with study
• Seeking treatment for AUD
• Meets The Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for AUD of at least moderate severity (\>3 symptoms)
• Inclusion Criteria (Healthy Volunteer Participants):
• Between the ages of 21 and 55
• Right-handed
• Able to perform informed consent and comply with study
• Report drinking an average of fewer than 8/15 standard drinks per week for women/men and no more than 1 HDD (heavy drinking days) during the previous 28 days.

Exclusion criteria

• Participants with Alcohol use Disorder):
• Neurological, medical or other conditions that would interfere with MRI scanning (e.g., history of stroke, seizure, brain tumor, brain infection, traumatic brain injury, multiple sclerosis, dementia, non MRI-compliant metal device in body, pregnancy, claustrophobia, color blindness, severe hearing impairment, weight\>300 lbs., wheelchair-bound, tattoos as indicated by the guidelines established by the Zuckerman Institute MRI unit: https://mr.research.columbia.edu/
• DSM 5 diagnoses of schizophrenia, schizoaffective disorder, or bipolar disorder
• Any non-AUD psychiatric disorder that may, according to the investigator's judgment, require treatment over the course of the study
• Significant suicide or violence risk
• Currently taking psychotropic medication
• Current substance use disorder other than AUD, tobacco use disorder or mild cannabis use disorder
• Currently pregnant, attempting to become pregnant or nursing
• Sufficiently socially unstable as to preclude participation (e.g. homeless).
• Known history of allergy, intolerance, or hypersensitivity to disulfiram or its derivates
• Contraindications to disulfiram treatment (e.g. liver disease, kidney disease, cardiac disease, seizure disorder, hypothyroidism, diabetes mellitus, pregnancy or lactation, allergy to disulfiram or thiuram derivatives)
• Currently taking medications containing alcohol, metronidazole, isoniazid, paraldehyde, phenytoin, warfarin, or theophylline.
• Treatment with concomitant medications that might interfere with disulfiram
• A history of alcohol withdrawal seizures, delirium tremens or resistant alcohol withdrawal
• Current moderate or severe alcohol withdrawal (CIWA \>9 with BAL\<0.05)
• History of prior disulfiram treatment failure
• Being abstinent for \> 7 days at the time of screening
• Exclusion Criteria (Healthy Volunteer Participants):
• Neurological, medical or other conditions that would interfere with MRI scanning (e.g., history of stroke, seizure, brain tumor, brain infection, traumatic brain injury, multiple sclerosis, dementia, non MRI-compliant metal device in body, pregnancy, claustrophobia, color blindness, severe hearing impairment, weight\>300 lbs., wheelchair- bound, tattoos as indicated by the guidelines established by the ZI MRI unit: https://mr.research.columbia.edu/
• DSM 5 diagnoses of schizophrenia, schizoaffective disorder, or bipolar disorder
• Any psychiatric disorder that may, according to the investigator's judgment, require treatment over the course of the study
• Significant suicide or violence risk
• Currently taking psychotropic medication
• Current substance use disorder other than tobacco use disorder or mild cannabis use disorder
• Currently pregnant, attempting to become pregnant or nursing
• Sufficiently socially unstable as to preclude participation (e.g., homeless).
• A diagnosis of AUD of any severity