Natural Course of Initially Metabolic Healthy Obese Individuals (Healthy Obesity)?
Recruiting · NCT06799897 · Observational (researchers observe without assigning treatment) · Lead sponsor: ETH Zurich
View the official record on ClinicalTrials.gov →What this trial is about
The main goal of this study is to gain a thorough understanding, which specific factors drive the unhealthy sequelae of obesity. Therefore, the investigators want to understand: 1. What distinguishes obese persons without metabolic diseases from those with medical diseases in a cross-sectional comparison? 2. Which factors drive the conversions from metabolically healthy obesity into a metabolically unhealthy obesity in a longitudinal approach?
Who can take part
Age range
18 Years to 60 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Signed Informed Consent Form
- Age between 18 and 60 years
- BMI 30-50 kg/m2
- Knowledge of German, which requires sufficient written and allow oral patient education
- Inclusion criteria for initially healthy group
- Blood pressure \< 140/90 mmHg
- Normal glucose metabolism
- HbA1c \< 6.5 %
- Fasting Glucose \< 7.0 mmol/l
- Normal lipid metabolism
- LDL-cholesterol \< 5.0 mmol/l
- ≤ 2 of the following metabolic syndrome criteria combined (excluding waist circumference)
- TG \> 1.7 mmol/l
- HDL-cholesterol \> 1.0 mmol/l (male) / \> 1.3 mmol/l (female)
- Fasting glucose ≥ 5.6 mmol/l
- BP ≥ 130/85 mmHg
Exclusion criteria
- Pregnancy
- Medication and / or pathologies that prevent a safe execution of the fat tissue biopsies
- History of or planned bariatric operation
- Medical conditions that prevent examinations and testing (e.g. symptomatic cardiovascular diseases)
- Active Malignant tumor (\<2a remission)
Where it is running
1 location listed.
- dTIP / ETH Zürich - Baden, Switzerland