Surveillance of Pancreatic Health After Diabetes Diagnosis
Recruiting · NCT06803771 · Interventional (participants receive a specific treatment) · Lead sponsor: University Hospital Southampton NHS Foundation Trust
View the official record on ClinicalTrials.gov →Interventions studied
Avantect Pancreatic Cancer Test
What this trial is about
The goal of this interventional study is to evaluate if the novel diagnostic blood test, called Avantect can early detect pancreatic cancer in patients diagnosed with type 2 diabetes within the last 6 months. Participants will: * attend 3 study visits over 12 months time * provide a blood sample at each study visit * complete an anxiety questionnaire at each visit.
Who can take part
Age range
50 Years to 84 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- 50 - 84 years of age at the time of enrolment (within year of birth, not month of birth)
- Haemoglobin A1c (HbA1c) ≥ 48 or 6.5% and/or confirmed type II DM diagnosed within the last 180 days (+20 days flexibility allowance)
- Willing to provide up to 30 mL of blood for each study visit
- Willing and eligible to undergo MRI scan (or CT scan if MRI is contraindicated)
- Understands the study process and is willing to take part in the study and sign the informed consent form
Exclusion criteria
- Prior type I or type II DM diagnosis \> 6 months
- A history of pancreatic cancer, pancreatic neuroendocrine tumour (pNET) or Pancreatitis
- Under investigation for pancreatic cancer / pancreatic cyst
- Any known pancreatic surgery (not including ERCP), or other major surgery requiring anaesthesia within 3 months
- Any invasive solid or haematological cancer in the past 3 years, including cancer recurrence after treatment in the last 3 years
- Current chronic or acute oral or systemic steroid use within 3 months of initial HbA1c or diabetes diagnosis (estimate rather than accurate)
- Blood transfusion within 1 month
- Solid organ transplant recipient
- Currently pregnant
- Needing dialysis
Where it is running
31 locations listed.
- Ashton Medical Group - Ashton-under-Lyne, United Kingdom
- Yardley Wood Health Centre - Birmingham, United Kingdom
- Bournemouth Research Hub - Bournemouth, United Kingdom
- Eastham Group Practice - Bromborough, United Kingdom
- Willesden Medical Centre - London, United Kingdom
- South Westminster Centre - London, United Kingdom
- The Cuckoo Lane Practice - London, United Kingdom
- Bodey Medical Centre - Manchester, United Kingdom
- Bowland Medical Practice - Manchester, United Kingdom
- The Maples Medical Centre - Manchester, United Kingdom
- King's Mill Hospital (Sherwood Forest) Research Van - Nottingham, United Kingdom
- Portsmouth Research Hub - Portsmouth, United Kingdom
- Hazelvalley Family Practice - Rossendale, United Kingdom
- Pembroke Centre (Hillingdon) - Ruislip, United Kingdom
- Southampton Research Hub (Shirley Research Hub) - Southampton, United Kingdom
- Moorgreen Hospital - Southampton, United Kingdom
- Civic Centre - Uxbridge, United Kingdom
- Quinton Practice - Walsall, United Kingdom
- Weymouth Research Hub - Weymouth, United Kingdom
- Ashfields Primary Care Centre - Sandbach, Cheshire, United Kingdom
- Maidstone and Tunbridge Wells NHS Trust - Maidstone, Kent, United Kingdom
- Balance Street Health Centre - Uttoxeter, Kent, United Kingdom
- Forest Medical Group - Leicester, Leicester Forest East, United Kingdom
- South Leicestershire Medical Group - Kibworth Beauchamp, Leicestershire, United Kingdom
- Peel Croft Surgery - Burton-on-Trent, Staffordshire, United Kingdom
- Kingswinford Medical Practice - Kingswinford, Staffordshire, United Kingdom
- Park Medical Centre - Leek, Staffordshire, United Kingdom
- Trinity Court Surgery - Stratford-upon-Avon, Staffordshire, United Kingdom
- Brockwood Medical Practice - Brockham, Surrey, United Kingdom
- Integrated Care Partnership/ The Old Cottage Hospital - Epsom, Surrey, United Kingdom
- Warlingham Green Medical Practice - Warlingham, Surrey, United Kingdom