Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula
Recruiting · NCT06807437 · Interventional (participants receive a specific treatment)
View the official record on ClinicalTrials.gov →Interventions studied
Biospecimen CollectionDistal PancreatectomyLanreotideQuestionnaire AdministrationSaline
What this trial is about
This phase III trial compares the effect of using lanreotide before surgery to surgery alone in preventing pancreatic fistulas in patients with pancreatic cancer or a pancreatic lesion that could become cancerous. Lanreotide, a type of somatostatin analog similar to somatostatin (a hormone made by the body), and is used to treat certain types of gastroenteropancreatic neuroendocrine tumors, and carcinoid syndrome. It may help stop the body from making extra amounts of certain hormones, including growth hormone, insulin, glucagon, and hormones that affect digestion. It may also help keep certain types of tumor cells from growing. Patients with pancreatic cancer or pancreatic lesions may undergo surgery to remove parts of the pancreas, also called a distal pancreatectomy. Patients may experience complications after surgery, including pancreatic fistulas. A pancreatic fistula occurs when there is a small leak from the pancreas, causing fluids to collect. This can often lead to infection and other problems. Giving lanreotide before undergoing distal pancreatectomy may be more effective than surgery alone in preventing the development of a pancreatic fistula in patients with pancreatic cancer or a pancreatic lesion that could become cancerous.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 3
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Participants must have histologically or radiographically confirmed diagnosis of pancreatic cancer or a pancreatic lesion with malignant potential
- Participants must have an elective distal pancreatectomy planned to occur within 60 days after registration/randomization date
- Participants must not have a known history of a prior diagnosis of malabsorption syndrome
- Participants must not have been treated with any somatostatin analogue within 180 days prior to registration/randomization
- Participants must not have been treated with radiation therapy for their pancreas malignancy at any time prior to registration/randomization
- Participants must not have been treated with peptide receptor radionuclide therapy (PRRT) at any time prior to registration/randomization
- Participants must be ≥ 18 years old
- Participants must have a complete documented medical history and physical exam within 28 days prior to registration/randomization
- Participants must have a creatinine ≤ the institutional upper limit of normal (IULN) OR a measured OR calculated creatinine clearance ≥ 50 mL/min using the following Cockcroft -Gault formula within 60 days prior to registration/randomization
- Participants must complete a pre-registration screening to identify any of the medications below, allowing the study team and treating physician to develop a monitoring plan as needed. Participants taking medications with known interactions with lanreotide may remain eligible if appropriate monitoring and management are in place. These medications include:
- Diabetes medications (insulin or oral hypoglycemics): Blood sugar will be monitored, and medication dose adjustments made as needed
- Cyclosporine: Dosage adjustments may be required to maintain therapeutic levels
- Bromocriptine: Dose adjustments may be considered to account for absorption changes
- Heart medications (e.g., beta blockers): Heart rate will be monitored, and medication doses adjusted if necessary
- CYP3A4-metabolized medications: Dose adjustments may be considered to avoid increased exposure
- In the opinion of the treating surgeon, based on preoperative data, the participant must not require a modified Appleby-type procedure (distal pancreatectomy with celiac axis resection) or multivisceral resection (e.g., stomach, colon, etc.) at the time of distal pancreatectomy
- NOTE: planned removal of the gallbladder or spleen at the time of distal pancreatectomy is not considered multivisceral resection and is permissible
- In the opinion of the treating surgeon, based on preoperative data, the participant must not require a tumor enucleation
- Participants must not have moderate to severe hepatic impairment as defined by liver enzyme elevation more than 5 times the institutional upper limit of normal (either aspartate aminotransferase \[AST\] \> 190 U/L or alanine aminotransferase \[ALT\] \> 320 U/L) within 60 days prior to registration/randomization. Transient elevation at the time of screening that resolves prior to study enrollment is acceptable
- Participants must not be pregnant or nursing (nursing includes breast milk fed to an infant by any means, including from the breast, milk expressed by hand, or pumped)
- Individuals who are of reproductive potential must have agreed to use an effective contraceptive method during the whole period of the study and for three months after the study drug administration, with details provided as a part of the consent process. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen
- Participants must be offered the opportunity to participate in specimen banking
- Participants who can complete EORTC QLQ-C30, EORTC QLQ-PAN26, and EQ-5D-5L forms in English or Spanish, must be offered the opportunity to participate in the quality-of-life study
- NOTE: As a part of the OPEN registration process, the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system.
- Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines
- For participants with impaired decision-making capabilities, legally authorized representatives may sign and give informed consent on behalf of study participants in accordance with applicable federal, local, and Central Institutional Review Board (CIRB) regulations
Where it is running
60 locations listed across 29 US states.
- University of Alabama at Birmingham Cancer Center - Birmingham, Alabama, United States
- Gulf Health Hospitals Inc/Infirmary Cancer Care - Malbis - Daphne, Alabama, United States
- Thomas Hospital - Fairhope, Alabama, United States
- Mobile Infirmary Medical Center - Mobile, Alabama, United States
- Gulf Health Hospitals Inc/Infirmary Cancer Care - Saraland - Saraland, Alabama, United States
- Banner MD Anderson Cancer Center - Gilbert, Arizona, United States
- City of Hope Comprehensive Cancer Center - Duarte, California, United States
- UC San Diego Moores Cancer Center - La Jolla, California, United States
- Veterans Affairs Loma Linda Healthcare System - Loma Linda, California, United States
- USC / Norris Comprehensive Cancer Center - Los Angeles, California, United States
- UC San Diego Medical Center - Hillcrest - San Diego, California, United States
- Helen F Graham Cancer Center - Newark, Delaware, United States
- Medical Oncology Hematology Consultants PA - Newark, Delaware, United States
- Christiana Care Health System-Christiana Hospital - Newark, Delaware, United States
- Christiana Care Health System-Wilmington Hospital - Wilmington, Delaware, United States
- Moffitt Cancer Center at SouthShore - Ruskin, Florida, United States
- Moffitt Cancer Center-International Plaza - Tampa, Florida, United States
- Moffitt Cancer Center - McKinley Campus - Tampa, Florida, United States
- Moffitt Cancer Center - Tampa, Florida, United States
- Moffitt Cancer Center at Wesley Chapel - Wesley Chapel, Florida, United States
- Grady Health System - Atlanta, Georgia, United States
- Emory University Hospital Midtown - Atlanta, Georgia, United States
- Emory University Hospital/Winship Cancer Institute - Atlanta, Georgia, United States
- Emory Saint Joseph's Hospital - Atlanta, Georgia, United States
- Emory Johns Creek Hospital - Johns Creek, Georgia, United States
- Northwestern University - Chicago, Illinois, United States
- University of Illinois - Chicago, Illinois, United States
- Northwestern Medicine Cancer Center Delnor - Geneva, Illinois, United States
- Northwestern Medicine Oak Brook - Oak Brook, Illinois, United States
- Northwestern Medicine Orland Park - Orland Park, Illinois, United States
- Northwestern Medicine Cancer Center Warrenville - Warrenville, Illinois, United States
- Indiana University/Melvin and Bren Simon Cancer Center - Indianapolis, Indiana, United States
- University of Kentucky/Markey Cancer Center - Lexington, Kentucky, United States
- University Medical Center New Orleans - New Orleans, Louisiana, United States
- Christiana Care - Union Hospital - Elkton, Maryland, United States
- University of Michigan Rogel Cancer Center - Ann Arbor, Michigan, United States
- Bronson Battle Creek - Battle Creek, Michigan, United States
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital - Grand Rapids, Michigan, United States
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital - Grand Rapids, Michigan, United States
- Trinity Health Grand Rapids Hospital - Grand Rapids, Michigan, United States
- Trinity Health Muskegon Hospital - Muskegon, Michigan, United States
- Corewell Health Lakeland Hospitals - Niles Hospital - Niles, Michigan, United States
- Cancer and Hematology Centers of Western Michigan - Norton Shores - Norton Shores, Michigan, United States
- Corewell Health Reed City Hospital - Reed City, Michigan, United States
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center - Saint Joseph, Michigan, United States
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital - Saint Joseph, Michigan, United States
- University of Michigan Health - West - Wyoming, Michigan, United States
- Riverwood Healthcare Center - Aitkin, Minnesota, United States
- Essentia Health - Baxter Clinic - Baxter, Minnesota, United States
- Essentia Health Saint Joseph's Medical Center - Brainerd, Minnesota, United States
- Essentia Health - Saint Joseph's Crosslake Clinic - Crosslake, Minnesota, United States
- Essentia Health - Deer River Clinic - Deer River, Minnesota, United States
- Essentia Health Saint Mary's - Detroit Lakes Clinic - Detroit Lakes, Minnesota, United States
- Essentia Health Cancer Center - Duluth, Minnesota, United States
- Essentia Health Saint Mary's Medical Center - Duluth, Minnesota, United States
- Miller-Dwan Hospital - Duluth, Minnesota, United States
- Essentia Health - Ely Clinic - Ely, Minnesota, United States
- Essentia Health - Fosston - Fosston, Minnesota, United States
- Essentia Health Hibbing Clinic - Hibbing, Minnesota, United States
- Essentia Health - International Falls Clinic - International Falls, Minnesota, United States
Showing 60 of 118 listed sites. See the official record for the complete list.
Read the full protocol, contacts and eligibility on ClinicalTrials.gov →