Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early Diagnosis
Recruiting · NCT06822413 · Observational (researchers observe without assigning treatment) · Lead sponsor: Second Affiliated Hospital, Zhejiang University, School of Medicine
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The goal of this observational study is to explore whether a Raman-based, deep learning-assisted approach can be used to develop an effective method for early pan-cancer screening. The study includes healthy individuals, patients at risk of cancer, and patients with diagnosed cancers. The main questions it aims to answer are: * Evaluating the deep-learning model's accuracy and specificity in identifying cancer-specific features in Raman spectral data and determining whether this method can accurately classify patients based on risk. * Identifying which model is more adaptable to the Raman spectrum * Providing an interpretable analysis of the model-generated diagnosis Participants are already being diagnosed and follow-up to determine the type of cancer.
Who can take part
Inclusion criteria
- Histopathological diagnosis of malignant tumors, including colorectal cancer, gastric cancer, hepatic cancer, pancreatic cancer, and esophageal cancer.
- Patients in normal physiological conditions without any malignant tumors or precancerous lesions.
- Patients with malignant tumor without recieving any interventions, including chemotherapy, surgery, radiotherapy, immunotherapy or other anti-tumor treatments.
- Patients with a histopathological diagnosis of any precancerous lesions or non-malignant disease.
Exclusion criteria
- Patients with metastatic tumors or in the condition with two or more kinds of malignant tumors at the same time
- Post-cancer treatment patients.
Where it is running
8 locations listed.
- The First Affiliated Hospital to Nanchang University - Nanchang, Jiangxi, China
- The Second Affiliated Hospital to Nanchang University - Nanchang, Jiangxi, China
- The First Affiliated Hospital to Nanchang University - Nanchang, Jiangxi, China
- The Second Affiliated Hospital to Nanchang University - Nanchang, Jiangxi, China
- Huashan Hospital Affiliated to Fudan University - Shanghai, Shanghai Municipality, China
- Huashan Hospital Affiliated to Fudan University - Shanghai, Shanghai Municipality, China
- The Second Affiliated Hospital of Zhejiang University School of Medicine - Hangzhou, Zhejiang, China
- The Second Affiliated Hospital of Zhejiang University School of Medicine - Hangzhou, Zhejiang, China