Advances in Imaging to Assess Response in Rectal Cancer
Recruiting · NCT06822634 · Observational (researchers observe without assigning treatment) · Lead sponsor: NHS Greater Glasgow and Clyde
View the official record on ClinicalTrials.gov →Interventions studied
Observational single centre feasibility study
What this trial is about
The goal of this observational study is to determine the feasibility of acquiring serial MRI images for advanced radiotherapy planning in colorectal patients. The main question it aims to answer: Is it feasible to acquire serial MR images for advanced radiotherapy planning for rectal cancer.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Histologically confirmed rectal adenocarcinoma.
- T stage 3b or above and/or high risk factors eg. EMVI, nodal disease.
- Participant able to give written informed consent.
- Male or non-pregnant female ≥18 years of age.
- Scheduled to undergo radical radiotherapy.
- Patients willing and able to comply with the protocol for the duration of study.
Exclusion criteria
- Contra-indications to MRI, such as claustrophobia, excessive body weight, MRI unsafe implants, ferrous metal in the body, insufficient information on prior surgeries. MRI conditional implants where conditions cannot be met (e.g pacemakers).
- Any previous radiotherapy to the pelvis.
- Inflammatory bowel disease.
- Other severe or uncontrolled systemic disease or evidence of any other significant disorder or lab finding that makes it undesirable for the patient to participate in the study, as determined by the treating clinician.
- History of physical or psychiatric disorder that would prevent informed consent and compliance with the protocol.
- Patients with de-functioning stoma.
- Major surgery within 28 days prior to trial entry.
Where it is running
1 location listed.
- Beatson West of Scotland Cancer Centre - Glasgow, United Kingdom