Melatonin Effects on Cardiovascular Disease Mechanisms in Midlife Women: A Randomized Clinical Trial
Recruiting · NCT06826755 · Interventional (participants receive a specific treatment) · Lead sponsor: Mayo Clinic
View the official record on ClinicalTrials.gov →Interventions studied
PlaceboTerry Naturally® melatonin 5mg SR
What this trial is about
The purpose of this research is to study the effects of 12 weeks of melatonin supplementation compared to placebo in women who are in the menopause transition (perimenopause) and have high blood pressure.
Who can take part
Age range
40 Years to 55 Years
Sex
Female
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age 40-55 years old
- Female individuals with intact uterus and at least one ovary
- Hypertension
- Defined as a prior diagnosis of hypertension, use of antihypertensive agents, or office SBP/DBP ≥130/80 mmHg
- On stable medical regimen (≥ 2 months) if taking other medications
Exclusion criteria
- Prescription sleeping medications or melatonin supplementation
- Pregnant or lactating
- Use of tobacco, nicotine or vaping products
- Night shift work
- On prescription aspirin
- Severe lactose intolerance
- History of substance use disorder
- History of suicidal ideation
- History of clinically diagnosed anemia (within the past 5 years) or low hemoglobin levels (\<11.6 g/dL) within the past 12 months
- Active cancer
- Severe daytime sleepiness (score \>15 at the Epworth Sleepiness Scale \[ESS\])81
- Current or recent (within the past 2 months) participation in other research studies at the discretion of study investigators
- Inability to provide written consent and/or to speak and read English
- Any other medical, geographic, or social factor making study participation impractical
Where it is running
1 location listed across 1 US state.
- Mayo Clinic in Rochester - Rochester, Minnesota, United States