A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease

Recruiting · NCT06830629 · Interventional (participants receive a specific treatment) · Lead sponsor: Maze Therapeutics

View the official record on ClinicalTrials.gov →

Interventions studied

MZE829

What this trial is about

The purpose of this study is to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with APOL1 Kidney Disease.

Who can take part

Age range

18 Years to 68 Years

Sex

All (male and female)

Healthy volunteers

No - a diagnosis or condition is required

Phase

Phase 2

Study type

Interventional (participants receive a specific treatment)

Inclusion criteria

APOL1 high risk genotype of G1/G1, G2/G2, or G1/G2
Chronic kidney disease with persistent albuminuria
Key

Exclusion criteria

Organ or bone marrow transplantation
History of active cancer within past 2 years, except for treated non-melanoma skin cancer, stage 0 cervical cancer, or stage 1 prostate cancer
Conditions that may alter drug absorption, e.g., history of bariatric surgery
Type I diabetes
Pregnant or currently nursing
ther inclusion/exclusion criteria defined in protocol apply.

Where it is running

60 locations listed across 24 US states.

Research Site - Decatur, Alabama, United States
Research Site - Huntsville, Alabama, United States
Research Site - Montgomery, Alabama, United States
Research Site - Montgomery, Alabama, United States
Research Site - Bloomfield, Connecticut, United States
Research Site - Washington D.C., District of Columbia, United States
Research Site - Atlantis, Florida, United States
Research Site - Brandon, Florida, United States
Research Site - Hollywood, Florida, United States
Research Site - Melbourne, Florida, United States
Research Site - Orlando, Florida, United States
Research Site - Atlanta, Georgia, United States
Research Site - College Park, Georgia, United States
Research Site - Cordele, Georgia, United States
Research Site - Macon, Georgia, United States
Research Site - Riverdale, Georgia, United States
Research Site - Riverdale, Georgia, United States
Research Site - Savannah, Georgia, United States
Research Site - Snellville, Georgia, United States
Research Site - Chicago, Illinois, United States
Research Site - Chicago, Illinois, United States
Research Site - Evanston, Illinois, United States
Research Site - Kansas City, Kansas, United States
Research Site - Bowling Green, Kentucky, United States
Research Site - Louisville, Kentucky, United States
Research Site - Arnold, Maryland, United States
Research Site - Lutherville, Maryland, United States
Research Site - Oxon Hill, Maryland, United States
Research Site - Dearborn, Michigan, United States
Research Site - Flint, Michigan, United States
Research Site - Pontiac, Michigan, United States
Research Site - Saint Joseph, Michigan, United States
Research Site - Minneapolis, Minnesota, United States
Research Site - Tupelo, Mississippi, United States
Research Site - City of Saint Peters, Missouri, United States
Research Site - St Louis, Missouri, United States
Research Site - Las Vegas, Nevada, United States
Research Site - Jersey City, New Jersey, United States
Research Site - Buffalo, New York, United States
Research Site - Laurelton, New York, United States
Research Site - Maspeth, New York, United States
Research Site - Newburgh, New York, United States
Research Site - Durham, North Carolina, United States
Research Site - Fayetteville, North Carolina, United States
Research Site - Greensboro, North Carolina, United States
Research Site - Shelby, North Carolina, United States
Research Site - Cleveland, Ohio, United States
Research Site - Cleveland, Ohio, United States
Research Site - Columbus, Ohio, United States
Research Site - Ardmore, Oklahoma, United States
Research Site - Philadelphia, Pennsylvania, United States
Research Site - Philadelphia, Pennsylvania, United States
Research Site - Upland, Pennsylvania, United States
Research Site - Columbia, South Carolina, United States
Research Site - Spartanburg, South Carolina, United States
Research Site - Spartanburg, South Carolina, United States
Research Site - Chattanooga, Tennessee, United States
Research Site - Dallas, Texas, United States
Research Site - Dallas, Texas, United States
Research Site - Greenville, Texas, United States

Showing 60 of 79 listed sites. See the official record for the complete list.

Read the full protocol, contacts and eligibility on ClinicalTrials.gov →