Atrioventricular Node Ablation and Conduction System Pacing in Patients With Well Controlled Permanent Atrial Fibrillation (AF), Heart Failure and Preserved Ejection Fraction: Heart Rate Regularization Versus Medical Rate Control
Recruiting · NCT06833138 · Interventional (participants receive a specific treatment) · Lead sponsor: French Cardiology Society
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The goal of this clinical trial is to assess the clinical efficacy of physiological pacing combined with atrioventricular node ablation, in patients with Heart Failure with preserved Ejection Fraction (HFpEF) and well controlled permanent atrial fibrillation.The main question it aims to answer is that heart rate regularization added to physiological pacing - preventing the deleterious effect of right ventricular apical pacing - would reduce mortality and heart failure hospitalizations. Researchers will compare physiological pacing combined with atrioventricular node ablation (intervention arm) versus optimal pharmacological therapy (control arm) to see if physiological pacing combined with atrioventricular node ablation reduce time to the composite of all-cause mortality or hospitalization due to heart failure or intravenous diuretics (time frame 24 months). Participants will : * Be randomized in intervention arm or control arm. * Visit the clinic 3 months, 12 months and 24 months after the randomization for checkups and tests.
Who can take part
Inclusion criteria
- Permanent atrial fibrilation \> 6 months
- Preserved Left Ventricular Ejection Fraction ≥ 50%
- ≥ 1 heart failure hospitalization in the previous year
- NYHA (New York Heart Association) score ≥ 2
- Presence of at least one of the following criteria related to diastolic dysfunction:
- E/e' ratio \> 9
- Left Ventricular mass \> 95 g/m2 (female) or \> 115 g/m2 (male) with h/R ratio \> 0.42
- NT pro BNP (B-type Natriuretic Peptide) \> 365 pg/mL or BNP (B-type Natriuretic Peptide) \> 105 pg/mL
- Narrow QRS ≤ 120 ms
- Average heart rate ≤ 110/min on 24 hours Holter monitoring
- Age over 18-year-old
- Capacity to understand the nature of the study, legal ability and willingness to give informed consent
- Patient covered by a social insurance
- Effective contraception and a negative pregnancy test in women of a childbearing age
Exclusion criteria
- Patient eligible for atrial fibrilation catheter ablation
- Life expectancy \< 12 months
- Severe chronic kidney disease (estimated Glomerular Filtration Rate ≤ 20 ml/1,73 m2)
- Severe respiratory disease (severe chronic obstructive pulmonary disease with Gold ≥ 3 and/or chronic oxygen therapy)
- Class III obesity (Body Mass Index ≥ 40)
- Confirmed or suspected infiltrative cardiomyopathy (amyloidosis, sarcoidosis, Fabry disease, others)
- Obstructive hypertrophic cardiomyopathy
- Previous implanted devices (Pacemaker / Implantable Cardioverter-Defibrillator / Cardiac Resynchronization Therapy)
- Other indication for pacemaker implantation
- Indication for implantable cardioverter-defibrillator
- Ambulatory ≤ 50% of time
- Pregnant women
- Breast-feeding women
Where it is running
17 locations listed.
- CHU de Besançon - Hôpital Jean Monjoz - Besançon, France
- CHRU de Caen - Hôpital Côte de Nacre - Caen, France
- CHRU de Tours - Hôpital Trousseau - Chambray-lès-Tours, France
- CHU de Clermont-Ferrand - Hôpital Gabriel Montpied - Clermont-Ferrand, France
- CHU Grenoble Alpes - Grenoble, France
- Groupe Hospitalier La Rochelle-Ré-Aunis - La Rochelle, France
- CHU de Lille - Institut Cœur-Poumons - Lille, France
- GHICL Allome - Hôpital St Philibert - Lomme, France
- Clinique Millenaire - Montpellier, France
- CHU de Nantes - Hôpital Nord Laennec - Nantes, France
- Institut Montsouris - Paris, France
- CHU de Bordeaux - Hôpital Cardiologique du Haut-Lévèque - Pessac, France
- CHU de Poitiers - Centre Cardiovasculaire - Poitiers, France
- CHU de Rennes - Hôpital Pontchallou - Rennes, France
- CHU de Rouen - Hôpital Charles Nicolle - Rouen, France
- Institut Arnault Tzanck - Saint-Laurent-du-Var, France
- CHRU de Nancy - Hôpitaux de Brabois - Vandœuvre-lès-Nancy, France