Study of Longitudinal Plasma PD-L1 Testing With Immunotherapy in Lung Cancer
Recruiting · NCT06849518 · Interventional (participants receive a specific treatment) · Lead sponsor: Ballad Health
View the official record on ClinicalTrials.gov →Interventions studied
Circulogene liquid biopsy testing
What this trial is about
This is a prospective pilot study to assess dynamic changes of plasma cell-free RNA (cfRNA) PD-L1 expression in patients with lung cancer undergoing immune checkpoint inhibitor (ICI) based therapy. Results will be correlated with radiographic assessment of immunotherapy treatment response and plasma NGS ctDNA.
Who can take part
Age range
No age limits stated
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- All patients with a diagnosis of stage IV or inoperable stage IIIB NSCLC without planned primary radiation therapy undergoing anti-PD-1/L1 based ICI treatment.
- Chemo-immune or dual anti-PD-1/L1 with anti-CTLA-4 based regimens are eligible as long as receiving an anti-PD-1/L1 monoclonal antibody.
- A documented informed consent will be obtained prior to inclusion in the study. All discussions with patients will be held in strictest confidence and out of earshot of the general public. Patients will be fully informed that their participation in the study is voluntary. Patients may decline to be part of the study. Their decision to participate in the study will not affect the care they receive.
Exclusion criteria
- No anti-PD-1/L1 monoclonal antibody treatment.
- Planned primary radiation therapy.
- Small-cell lung cancer histology.
Where it is running
1 location listed across 1 US state.
- Ballad Health Cancer Care - Kingsport, Tennessee, United States