Acoustic Cluster Therapy (ACT) With Chemotherapy for the Treatment of Locally Advanced Pancreatic Cancer
Recruiting · NCT06850623 · Interventional (participants receive a specific treatment) · Lead sponsor: EXACT Therapeutics AS
View the official record on ClinicalTrials.gov →Interventions studied
Acoustic Cluster TherapyModified FOLFIRINOX
What this trial is about
The purpose of the study is to assess the efficacy and safety of Acoustic Cluster Therapy (ACT) when given in addition to chemotherapy for treatment of Locally Advanced Pancreatic Cancer.
Who can take part
Age range
18 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 2
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Not deemed suitable for primary curative surgery and have radiographic and pathological disease consistent with inoperable LAPC or borderline resectable pancreatic cancer.
- Suitable to receive treatment with mFOLFIRINOX according to the Investigator's assessment.
Exclusion criteria
- Any prior anti-cancer treatment for pancreatic cancer (e.g. chemotherapy, surgery, radiation). Palliative bypass procedure and bile duct stenting are allowed.
Where it is running
10 locations listed across 6 US states.
- HonorHealth Research Institute - Scottsdale, Arizona, United States
- Stanford Cancer Center Palo Alto - Stanford, California, United States
- Beth Israel Deaconess Medical Center - Division of Hematology/Oncology - Boston, Massachusetts, United States
- Henry Ford Centre - Detroit, Michigan, United States
- Sidney Kimmel Cancer Center, Thomas Jefferson University Hospital - Philadelphia, Pennsylvania, United States
- Allegheny General Hospital - Pittsburgh, Pennsylvania, United States
- Brown University Cancer Institute - Providence, Rhode Island, United States
- CAMBRIDGE CANCER TRIALS CENTRE-Addenbrooke's Hospital - Cambridge, Cambridge, United Kingdom
- Gary Weston Centre- Imperial College Healthcare- Du Cane Road - Hammersmith, London, United Kingdom
- The Royal Marsden- Downs Road - Sutton, Surrey, United Kingdom