Brain and Behavior Influences on Obesity Development From Infancy Through Childhood
Recruiting · NCT06861868 · Interventional (participants receive a specific treatment) · Lead sponsor: Johns Hopkins University
View the official record on ClinicalTrials.gov →Interventions studied
Ad libitum meal testEating in the absence of hunger testfMRI cue reactivity taskfMRI go no go task
What this trial is about
The investigators project, RESONATE, aims to investigate why some children develop obesity. To do this it uses data on eating and eating-related behaviors, genetic and environmental factors, and brain structure and function. This data is collected in a sub-sample of RESONANCE, a large study of families of children from infancy through childhood. The results will lay foundations for the development of early interventions to prevent or treat obesity.
Who can take part
Age range
7 Years to 12 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Participants from the RESONANCE cohort are eligible if the participant will reach 7-12 years of age during the proposed project period and have no food allergies.
Exclusion criteria
- Exclusion criteria for RESONANCE include:
- In utero exposure to alcohol, cigarette, or illicit substances;
- First trimester fetal US abnormalities;
- Complicated pregnancy (e.g., pre-eclampsia);
- Complicated delivery, including APGAR scores less than 8 and/or neonatal intensive care unit (NICU) admission;
- History of neurological (e.g., epilepsy), psychiatric (e.g., anxiety or depression requiring treatment with medication) or developmental disorder (e.g., autism spectrum disorder (ASD), dyslexia);
- Contraindications for MRI including metal in the body, claustrophobia.
Where it is running
4 locations listed across 3 US states.
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc. - Baltimore, Maryland, United States
- Johns Hopkins University School of Medicine - Baltimore, Maryland, United States
- Rhode Island Hospital - Providence, Rhode Island, United States
- University of Washington - Seattle, Washington, United States