Rheological Functions of Erythrocyte in ESRD
Recruiting · NCT06868888 · Observational (researchers observe without assigning treatment) · Lead sponsor: Chang Gung Memorial Hospital
View the official record on ClinicalTrials.gov →Interventions studied
Blood collectionCardiopulmonary exercise testing (CPET)
What this trial is about
End-stage renal disease (ESRD) disrupts erythrocyte deformability due to osmotic imbalances, oxidative stress, and uremic toxins, leading to impaired microcirculation and oxygen transport. Dysregulation of ion channels, particularly the Gardos channel, exacerbates dehydration and eryptosis, further compromising vascular integrity. Given the critical role of erythrocyte flexibility in oxygen delivery, this study investigates its relationship with aerobic capacity in ESRD patients, highlighting potential mechanisms of microvascular dysfunction
Who can take part
Age range
20 Years and older
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Receiving hemodialysis and medication at least for 6 weeks
- Kt/V score \> 1.2
Exclusion criteria
- Under 20 years-old
- Hyperkalemia occurs within 3 month
- Having orthopedic or muscular diseases
- Other concerned medical, psychological or physiological diseases
- Pregnancy
- Other exercise contraindications
Where it is running
1 location listed.
- Chang Gung University - Taoyuan, Taiwan