Cardiovascular and Endothelial Markers During OGTT Before and at Six and Twelve Months Post-treatment in Women With PCOS
Recruiting · NCT06889454 · Observational (researchers observe without assigning treatment) · Lead sponsor: Attikon Hospital
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The aim of the present study is to investigate a) the presence of subclinical markers of vascular, myocardial and endothelial function in women with PCOS b) the acute alterations in these markers during the oral glucose tolerance test (OGTT) c) the impact of potential treatment interventions in these markers.
Who can take part
Age range
18 Years to 45 Years
Sex
Female
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Age \> 16 years old
- Diagonis of PCOS according to Rotterdam criteria: presence of two of the three of the following:
- Clinical or biochemical hyperandrogenism
- Anovulation or oligo-ovulation
- Polycystic ovarian morphology (PCOM)
- Absence of treatment for PCOS the last six months
- Patients who have the ability to understand and sign the consent form.
Exclusion criteria
- Disorders with clinical presentation similar to PCOS: thyroid disease, hyperprolactinemia, and non-classic congenital adrenal hyperplasia (primarily 21-hydroxylase deficiency by serum 17-hydroxyprogesterone \[17-OHP\]), Cushing syndrome, acromegaly
- Treatment with contraceptive or metformin
- Type 2 diabetes mellitus
- Treatment for diabetes
- Pregnancy
- Lactation
- Malignancy
Where it is running
1 location listed.
- Attikon University General Hospital - Chaïdári, Greece