Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)
Recruiting · NCT06892210 · Interventional (participants receive a specific treatment) · Lead sponsor: Copenhagen Respiratory Research
View the official record on ClinicalTrials.gov →Interventions studied
HydrocortisoneMethylprednisolone (drug)
What this trial is about
The goal of this cluster randomized controlled trial is to determine the optimal treatment for Acute Exacerbation of Chronic Obstructive Pulmonary Disease. The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 40 years old diagnosed with chronic obstructive pulmonary disease with acute exacerbation. The main question is whether there is a difference in readmission for COPD excerbation or all cause mortality within thirty days. Participants will randomized to receive treatment with either hydrocortisone or prednisolone.
Who can take part
Age range
40 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Phase 4
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age ≥40 years
- Chronic obstructive pulmonary disease with acute exacerbation, unspecified: ICDJ44
Exclusion criteria
- All diagnoses that would merit treatment with a specific corticosteroid
- Pregnant or breastfeeding women
- Active tuberculosis or invasive fungal infection
Where it is running
14 locations listed.
- Bornholm Hospital - Rønne, Bornholm, Denmark
- Amager Hospital - Copenhagen, Copenhagen City, Denmark
- Bispebjerg Hospital - Copenhagen, Copenhagen City, Denmark
- Frederiksberg Hospital - Frederiksberg, Copenhagen City, Denmark
- Gentofte Hospital - Hellerup, Copenhagen City, Denmark
- Herlev Hospital - Herlev, Copnhagen Surroundings, Denmark
- Hvidovre Hospital - Hvidovre, Copnhagen Surroundings, Denmark
- Nordsjællands Hospital - Hillerød, North Zealand, Denmark
- Holbæk Sygehus - Holbæk, Region Sjælland, Denmark
- University Hospital of Region Zealand, Køge - Køge, Region Sjælland, Denmark
- Næstved Sygehus - Næstved, Region Sjælland, Denmark
- Ringsted Sygehus - Ringsted, Region Sjælland, Denmark
- University Hospital of Region Zealand, Roskilde - Roskilde, Region Sjælland, Denmark
- Slagelse Sygehus - Slagelse, Region Sjælland, Denmark