Cortisol and Obesity - A Vicious Cycle? Hypoglycemia After Bariatric Surgery - Association With Cortisol Metabolism?
Recruiting · NCT06896682 · Observational (researchers observe without assigning treatment) · Lead sponsor: Esbjerg Hospital - University Hospital of Southern Denmark
View the official record on ClinicalTrials.gov →What this trial is about
The goal of this observational study is to learn about how bariatric surgery affects the metabolism of cortisol. The main question it aims to answer is whether changes in cortisol contribute to the development of reactive hypoglycemia? 100 individuals who have previously undergone bariatric surgery, are planned to be included.
Who can take part
Age range
No age limits stated
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Participants must have undergone one of the following bariatric procedures at least 12 months prior:
- Roux-en-Y gastric bypass
- Gastric sleeve
Exclusion criteria
- Pregnancy and breastfeeding
- Nephrotic syndrome (kidney disease with protein loss in urine), liver cirrhosis, or severe malnutrition, as these conditions reduce cortisol-binding globulin (CBG) levels, affecting total cortisol concentration
- Use of corticosteroid medications, such as prednisolone
- Use of opiod-containing medication
- Use of medications containing estrogen, such as hormone therapy for menopause
- Known adrenal disease affecting cortisol metabolism, including autonomous cortisol production and Cushing's syndrome
- Diabetes that does not require medical treatment
- Previously diagnosed reactive hypoglycemia after bariatric surgery requiring medical treatment
Where it is running
1 location listed.
- Esbjerg Hospital - Esbjerg, Denmark