Fecal Calprotectin for Prediction of Esophageal Varices in Cirrhotic Patients
Recruiting · NCT06908798 · Observational (researchers observe without assigning treatment) · Lead sponsor: Tanta University
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The goal of this cross-sectional observational study is to evaluate the accuracy of fecal calprotectin versus non-invasive scores in assessing the presence and grading of esophageal varices in Egyptian patients. Researchers will compare fecal calprotectin levels in cirrhotic patients with and without esophageal varices (EVs) and healthy subjects. researchers will also evaluate the performance of fecal calprotectin, AST to platelet ratio index (APRI) score, fibrosis-4 (FIB-4) score, albumin-bilirubin (ALBI) score, platelet-albumin-bilirubin (PALBI) score, and platelet-spleen diameter ratio (PSR) for predicting esophageal varices. Participants will undergo history-taking, clinical examination, laboratory investigations, fecal calprotectin, abdominal ultrasonography, and upper endoscopy. Endoscopic grading of esophageal varices will be done using Paquet's classification. The APRI, FIB-4, ALBI, PALBI, and PSR scores will be calculated. The performance of fecal calprotectin for predicting EVs will be compared versus other non-invasive scores.
Who can take part
Inclusion criteria
- Age ≥18 years
- Liver cirrhosis
Exclusion criteria
- Patients aged \< 18 years.
- Inflammatory bowel disease.
- Infectious gastroenteritis.
- Malignancy.
- Patients on proton pump inhibitors or NSAID.
- Patients with spontaneous bacterial peritonitis.
- Patients with hepatic encephalopathy.
- Unwilling to participate in our study.
Where it is running
1 location listed.
- Tanta University Hospitals - Tanta, Gharbyea, Egypt