Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
Recruiting · NCT06911229 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Florida
View the official record on ClinicalTrials.gov →Interventions studied
Deep Brain Stimulation (DBS)
What this trial is about
Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.
Who can take part
Age range
18 Years to 80 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- consensus diagnosis of idiopathic PD by fellowship trained movement disorders neurologists at the Normal Fixel Institute of Neurological Diseases;
- chronically stable DBS, defined as having had DBS for at least 6 months in duration with optimized DBS settings;
- Age between 18 - 80 years old per the FDA data sheet for PD DBS;
- no dementia according to the clinical diagnostic criteria for PD dementia;
- ambulatory without the use of walking aids, or another person's assistance.
Exclusion criteria
- other previous neurological surgery;
- suspicion of other neurologic diagnoses such as atypical parkinsonism, or Alzheimer's disease.
Where it is running
1 location listed across 1 US state.
- University of Florida - Gainesville, Florida, United States