Characteristics of Papez Loop Neural Network in T2DM （Type 2 Diabetes Mellitus）
Recruiting · NCT06912321 · Observational (researchers observe without assigning treatment) · Lead sponsor: Nanjing First Hospital, Nanjing Medical University
View the official record on ClinicalTrials.gov →Interventions studied
No Intervention: Observational Cohort
What this trial is about
This is a cross-sectional and longitudinal study to investigate the characteristic changes in Papez's circuit neural network activity and connectivity based on multimodal MRI, and through follow-up study of the interaction between the internal brain regions of Papez circuit and the function of the external neural network, a prediction model of the characteristic changes of Papez circuit neural network was constructed based on machine learning technology.
Who can take part
Age range
45 Years to 70 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- T2DM patients met the diagnostic criteria for diabetes (WHO, 1999) with a duration of 3-20 years; The control group met the criteria of fasting blood glucose \< 6.1mmol/l and glycosylated hemoglobin \< 5.7%;
- right-handed, aged 45-70 years, with ≥8 years of education;
- no contraindications to MRI scanning such as electronic and metal device implantation;
- The visual acuity or corrected visual acuity and binaural hearing can meet the needs of the evaluation, and can cooperate to complete the examination.
- without a history of substance abuse or dependence, evaluation is not used during the period of calm sleeping pills and antidepressants, not long-term use of drugs to improve cognitive.
Exclusion criteria
- patients with acute metabolic complications or a history of severe hypoglycemia;
- severe heart, liver, lung, kidney and hematopoietic system diseases; Hyperthyroidism or hypothyroidism; Stroke, alzheimer's disease, epilepsy, Parkinson's disease and other neurological history; A history of mental illness such as depression, mania, or alcohol dependence; History of loss of consciousness due to neurological diseases or traumatic brain injury;
- one month before the laboratory examination, with a record and surgical trauma infection;
Where it is running
1 location listed.
- Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University - Nanjing, Jiangsu, China