Digital Solutions in Heart Therapy (DIGNITY)

Inclusion criteria

• Age \> 18 years at the time of hospital admission
• Ability to use a (smart)phone and/or tablet for the follow-up
• Documented left ventricular ejection fraction (LVEF) \> 40% assessed within preceding 12 months
• Not treated with optimal doses of oral HF therapies within 2 days before anticipated hospital discharge for acute HF in at least one of the medication categories (for details see Table 1 on page 10)
• Hospitalized due to acute HF decompensation.
• Specific measures within 24 hours prior to randomization
• Systolic blood pressure \> 100 mmHg, and heart rate \> 60bpm
• Serum potassium \< 5mmol/L

Exclusion criteria

• Inability to use a (smart)phone or tablet
• Clear intolerance to high doses of betablockers, ACE inhibitors, or ARBs
• Estimated glomerular filtration rate \<30ml/min/1.73m2 or dialysis
• Myocardial infarction, unstable angina or cardiac surgery within 3 months, percutaneous transluminal coronary intervention within 1 months prior to screening
• Cardiac resynchronization therapy device implantation within 3 months prior to screening
• Presence of significant obstructive lesion of the left ventricular outflow tract
• Amyloid cardiomyopathy
• Participation in other clinical trials for drugs
• Pregnant or nursing women
• Women of child-bearing potential who are unwilling to abstain from sexual intercourse with men or practice appropriate contraception