Vaping and Smoking Project in People With Schizophrenia
Recruiting · NCT06944847 · Interventional (participants receive a specific treatment) · Lead sponsor: State University of New York at Buffalo
View the official record on ClinicalTrials.gov →Interventions studied
Acute (24-hour) abstinenceAd libitum smoking/vaping
What this trial is about
The proposed research will characterize withdrawal among people with schizophrenia who vape daily compared to people with schizophrenia who smoke combustible cigarettes daily, filling critical gaps in the understanding of electronic nicotine delivery systems (ENDS) dependence and contributing to the development of vaping cessation interventions amongst people with schizophrenia, the leading preventable cause of death in the US.
Who can take part
Age range
21 Years to 50 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- 6+ months of daily/near-daily nicotine vaping or cigarette smoking
- 200+ ng/mL cotinine on a commercially-available quick screen
- stable antipsychotic medication dose (no changes in past 6 months).
- Current
Exclusion criteria
- intention to quit daily/near-daily vaping/smoking in the next month
- current (2+ days out of the past 7) use of pipe tobacco, hookah/shisha, smokeless tobacco, dissolvable tobacco, nicotine pouches. For vaping group only, current (2+ days out of past 7) use of cigars, cigarillos, or filtered cigars that are filled with tobacco or a mix of tobacco and marijuana
- current use of any smoking cessation medication
- current severe substance dependence other than tobacco/nicotine (including cannabis; NIDA Modified ASSIST of 27+)
- current (past 2 weeks) suicidal ideation with intent and/or plan
- pregnancy (intake urine screen)
- florid psychosis or severe cognitive symptoms (score of ≥5 on PANSS items delusions (P1), hallucinatory behavior (P3), or unusual thought content (G9), conceptual disorganization (P2), abstract thinking (N5), or poor attention (G11) or a score ≥6 on grandiosity (P5) or suspiciousness (P6)
Where it is running
1 location listed across 1 US state.
- University at Buffalo - Buffalo, New York, United States