Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy

Recruiting · NCT06948058 · Interventional (participants receive a specific treatment) · Lead sponsor: Brown University

Interventions studied

Electronic Cigarettes (EC)Nicotine replacement therapy (NRT)

This project will investigate the effects of alternative nicotine products on smoking, weight gain, and related outcomes.

Age range

21 Years and older

Sex

All (male and female)

Healthy volunteers

No - a diagnosis or condition is required

Phase

Not applicable (e.g. observational or device study)

Study type

Interventional (participants receive a specific treatment)

body mass index (BMI) ≥ 30 kg/m2 (i.e., obese)
smoked ≥ 5 cigarettes/day during the past year
21 or older (due to minimum legal age EC restrictions)
exhaled breath carbon monoxide (CO) level \> 6 ppm at Baseline (BL) (to confirm self-reported smoking)
willing to use EC or NRT for 8 weeks
access to a Bluetooth-enabled smartphone/tablet (to permit remote measurement of CO and other outcome variables)

received smoking cessation treatment of any kind in the past 30 days (actively quitting smoking),
currently using EC or NRT more than 2 days/week (this may affect responses to study-supplied products)
hospitalized for mental illness in past 30 days
heart-related event (e.g., heart attack, severe angina) in past 30 days
residing with another person currently enrolled in the study
pregnant, nursing, or planning to become pregnant in the next 6 months
medical contraindication for study or product use (e.g., allergy to adhesives)
taken prescription weight loss medication in the last 30 days

1 location listed across 1 US state.