Comparison of Phaco Surgery With Goniosynechialysis Versus Trabeculectomy in Glaucoma Treatment
Recruiting · NCT06952153 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Medicine and Pharmacy at Ho Chi Minh City
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The goal of this clinical trial is to learn whether phacoemulsification combined with goniosynechialysis (Phaco-GSL) is as effective and safe as trabeculectomy in treating patients with primary angle-closure glaucoma. The main questions it aims to answer are: * Does Phaco-GSL provide similar or better intraocular pressure (IOP) control compared to trabeculectomy? * What are the rates of postoperative complications or adverse events between the two surgical approaches? * How do the two procedures compare in terms of visual acuity recovery and need for glaucoma medications? Researchers will compare Phaco-GSL to trabeculectomy to determine which procedure offers better overall outcomes for patients with angle-closure glaucoma. Participants will: Be randomly assigned to undergo either Phaco-GSL or trabeculectomy Attend scheduled follow-up visits at regular intervals (e.g., 1 week, 1 month, 3 months, 6 months, 12 months) for eye exams and pressure checks
Who can take part
Inclusion criteria
- Age ≥ 40 years
- Peripheral anterior synechiae (PAS) \>180°
- Glaucomatous optic neuropathy with visual field loss
- Intraocular pressure (IOP) \> 21 mmHg despite medication
- Ability to consent and comply with follow-up
- Cataract grade 1 to 3 according to LOCS III
- Best corrected visual acuity (BCVA) ≥ 0.3 logMAR (equivalent to 20/40 Snellen or worse)
Exclusion criteria
- Very advanced glaucoma (only light perception vision)
- Secondary angle-closure etiologies
- Prior ocular surgeries or laser peripheral iridotomy (PI)
- Allergy to 5-fluorouracil (5-FU), if used postoperatively
- Irreversible corneal disease
- Chronic corticosteroid use
- Poor follow-up compliance
- Cataract grade 4 or 5 (LOCS III)
- Phacomorphic, phacolytic, or subluxated cataracts
Where it is running
1 location listed.
- HCMC University of Medicine and Pharmacy - Ho Chi Minh City, Vietnam