Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI
Recruiting · NCT06955832 · Observational (researchers observe without assigning treatment) · Lead sponsor: Benha University
View the official record on ClinicalTrials.gov →What this trial is about
The goal of this observational study is to compare the diagnostic accuracy of Phase-Sensitive Inversion Recovery (PSIR) MRI versus conventional T2-weighted (T2W) and Fluid Attenuated Inversion Recovery (FLAIR) sequences in detecting early brain lesions in patients with Multiple Sclerosis (MS). The study will include male and female participants aged 15-65 years diagnosed with MS per the 2017 McDonald criteria. This study hypothesizes that: * PSIR MRI will detect a significantly higher number of cortical lesions (intracortical, leukocortical, and juxtacortical) compared to conventional T2W and FLAIR sequences in MS patients (p \< 0.05). * Lesions identified exclusively by PSIR will correlate more strongly with clinical measures (EDSS disability scores and SDMT cognitive performance) than those detected by T2W/FLAIR alone, suggesting PSIR's superior sensitivity to clinically relevant pathology.
Who can take part
Inclusion criteria
- Age between 15-65 years.
- Both sexes.
- Patients with MS according to McDonald Criterion
Exclusion criteria
- Age less than 15 years old.
- Patients with stroke or previous intracranial hemorrhage.
- Contraindications to MRI scans.
- MS mimics.
Where it is running
3 locations listed.
- El Mounira Multiple Sclerosis Unit - Cairo, Egypt
- Naser Institute MS Unit - Cairo, Egypt
- Banha University Hospitals - Banhā, Qalyubia Governorate, Egypt