Development and Validation of Microbiota and Metabolite-based Prediction Model for Recurrence of High-risk Colorectal Polyps After Polypectomy
Recruiting · NCT06957626 · Observational (researchers observe without assigning treatment) · Lead sponsor: Peking Union Medical College Hospital
View the official record on ClinicalTrials.gov →What this trial is about
The characteristics of the intestinal microbiota in high-risk colorectal polyp recurrence and their relationship with disease pathogenesis have not yet been fully elucidated. This study aims to analyze the microbial community characteristics in the intestinal mucosal tissue of patients after polypectomy with recurrence of colorectal polyps. Additionally, this research holds significant importance for understanding the etiology of adenoma recurrence and develop a microbiota and metabolite-based predicting tool.
Who can take part
Age range
40 Years to 75 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- patients aged 40-75 years who undergo the colonoscopy with at least 1 advanced premalignant polyps or ≥ 3 adenoma
Exclusion criteria
- patient with severe physical diseases that prevented them from adhering to the examination requirements,
- patient with coagulopathy or other contraindications for biopsy or polypectomy,
- patient with previous surgical procedures on the gastrointestinal tract,
- presence of colorectal cancer or other malignant tumor at baseline
- presence of inflammatory bowel disease or hereditary polyposis syndromes (such as family adenomatous polyposis or Lynch syndrome)
- within 1 month before enrollment, oral antibiotics and probiotics were taken;
- inability to provide informed consent or refusal to participate in the study.
Where it is running
1 location listed.
- Peking Union Medical College Hospital, 1 Shuaifuyuan, Dongcheng District, Beijing, China - Beijing, China