tdCS Combined With Treadmill Training in Patients With Multiple Sclerosis
Recruiting · NCT06986278 · Interventional (participants receive a specific treatment) · Lead sponsor: University of Castilla-La Mancha
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
This clinical trial aims to evaluate the therapeutic effectiveness of transcranial direct current stimulation (tDCS), a non-invasive technique that modulates cortical excitability, in combination with gait training in patients with multiple sclerosis (MS). The study focuses on improving balance and walking ability, which are commonly impaired in this population. A randomized, triple-blind, controlled design will be used, comparing an active tDCS group with a sham stimulation group, both receiving the same gait training protocol. Outcomes will include functional and clinical measures related to mobility, balance, and fatigue. The project builds on previous meta-analytical evidence suggesting positive effects of tDCS in MS and aims to confirm these findings using an optimized stimulation protocol.
Who can take part
Inclusion criteria
- Ability to understand and follow instructions.
- Diagnosis of Multiple Sclerosis according to McDonald criteria.
- Expanded Disability Status Scale (EDSS) between 1 and 6.
- Stable condition in the last three months.
Exclusion criteria
- Peripheral neurological injury of lower limbs.
- Metal objects in the head.
- Uncontrolled epilepsy.
- Diagnosis of psychiatric disorder.
- Fractures or fissures in the skull.
- Presence of any implanted electronic device (pacemaker, baclofen pump).
- Presence of ulcers in the harness attachment area.
- Osteoporotic fractures in the last 2 years.
- Height \> 190 cm.
- Weight \> 120 kg.
Where it is running
2 locations listed.
- Asociación de Esclerosis Múltiple de Toledo - Toledo, Toledo, Spain
- Universidad de Castilla La Mancha - Toledo, Toledo, Spain