HOme-based Brain Monitoring With a GARment-EEG to Study Cognitive Decline in the Aging Population

Inclusion criteria

• Native Spanish speaker.
• Agree to the examination procedures and tests.
• Ability to involve a close family member or friend for functional evaluation.
• Normal or corrected-to-normal color vision.
• No medical condition requiring chronic systemic medication with psychoactive effects causing confusion.
• No severe psychiatric (according to DSM-V) or neurological diseases (epilepsy with frequent seizures (\>1/month) in the last year, multiple sclerosis, etc.).
• No diseases that may interfere with cognitive functions (renal insufficiency on hemodialysis, liver cirrhosis, chronic pulmonary disease with oxygen therapy, solid organ transplant, fibromyalgia, active cancer under treatment).
• No severe hearing and/or visual impairments, neurodevelopmental, or psychomotor disorders.
• No brain injuries that may interfere with cognitive functions (history of traumatic brain injury with parenchymal injury or macroscopic ischemic stroke of large extra-axial vessels or hemorrhagic stroke, brain surgery, brain tumors, or other causes that could result in acquired brain damage such as brain chemotherapy or radiotherapy).
• No treatment with antipsychotic agents in the 6 months prior to the initial assessment.
• No medical condition requiring chronic systemic medication with psychoactive effects causing confusion. No psychiatric or neurological medication.
• No alcohol or drug abuse.
• No serious health problems in the last 12 months (especially neurological or cardiac disorders).
• Inclusion Criteria 'Mild Dementia' group:
• Diagnosis of Alzheimer's type dementia, based on a clinical and cognitive assessment conducted by a physician.
• Diagnosis of vascular or mixed type dementia, based on a clinical and cognitive assessment conducted by a physician.
• Lack of autonomy in: 1. basic activities according to the Barthel Index; 2. instrumental activities according to the Lawton Index. Both indices assess dependence associated with the diagnosis of dementia, distinguishing it from the diagnosis of mild cognitive impairment.
• Inclusion Criteria 'Mild Cognitive Impairment' group:
• Diagnosis of mild cognitive impairment, based on a clinical and cognitive assessment conducted by a physician.
• Preserved autonomy in: 1. basic activities according to the Barthel Index; 2. instrumental activities according to the Lawton Index. Both indices assess dependence associated with the diagnosis of dementia, distinguishing it from the diagnosis of mild cognitive impairment
• Inclusion Criteria 'Subjective Cognitive Decline' group:
• Adherence to SCD-I criteria.
• Attendance at primary care consultation with memory complaints lasting more than 6 months.
• Absence of a diagnosis of mild cognitive impairment or dementia.
• Onset of subjective cognitive decline in the last 5 years.
• Concerns related to subjective cognitive decline (not associated with an acute event) expressed by the participant and/or an informant.
• Cognitive performance within the normal range on cognitive tests (MMSE (Mini Mental State Exam) \< 26 / MIS (Memory Impairment Screen) \< 6).
• No severe depressive symptoms, indicated by scores \> 17\* on the 30-item Geriatric Depression Scale.
• Inclusion criteria No impairment group:
• Cognitive performance within the normal range on cognitive tests (MMSE \< 26 / MIS \< 6).
• Absence of a diagnosis of mild cognitive impairment or dementia.
• Not meeting the criteria for SCD-I \[21\].
• Independent person living in their own home.
• No subjective memory complaints.