Cerebellar Transcranial Alternating Current Stimulation (tACS) to Modulate Parkinson's Disease Tremor
Recruiting · NCT06993571 · Interventional (participants receive a specific treatment) · Lead sponsor: Universitätsklinikum Hamburg-Eppendorf
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by different motor symptoms, including tremor, which is particularly difficult to manage. Common treatments, such as dopaminergic therapy, can have limitations in efficacy. Recent advancements in non-invasive brain stimulation, specifically phase-adaptive transcranial alternating current stimulation (tACS), offer a promising approach to reduce PD tremor. In the current project, a newly developed closed-loop system delivers precisely synchronized cerebellar tACS by aligning stimulation with the intrinsic hand tremor signal. The study will assess the efficacy of this novel approach to reduce hand tremor in PD patients.
Who can take part
Inclusion criteria
- Clinical diagnosis of Parkinson's disease based on UK Brain Bank criteria
- Patient exhibiting moderate to severe hand tremor
- Provision written informed consent by the patient
Exclusion criteria
- History of other neurological disorders such as vascular malformations, ischemic or haemorrhagic stroke, cerebral neoplasia, epilepsy, or major psychiatric illness
- Existence of heart pacemaker or metal implants in the body
- Pregnancy
Where it is running
1 location listed.
- Universitätsklinikum Hamburg-Eppendorf - Hamburg, Free and Hanseatic City of Hamburg, Germany