Bile Omics for Diagnosing Indeterminate Biliary Strictures
Recruiting · NCT07007832 · Observational (researchers observe without assigning treatment) · Lead sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The diagnosis of malignant biliary strictures remains a challenging aspect of biliary endoscopy. Molecular biological testing techniques based on bile have been reported to improve detection rates. However, whether the combination of bile-based omics studies and biliary brush cytology/biopsy can enhance diagnostic sensitivity has not yet been reported. This study aims to collect bile from patients with malignant biliary strictures, screen for molecular markers associated with biliary malignancies through multi-omics analysis, and subsequently validate these markers to establish a bile-based molecular diagnostic model.
Who can take part
Inclusion criteria
- Indeterminate biliary strictures
- Aged 18-90 years
- Underwent ERCP with biliary biopsy and/or brush cytology
Exclusion criteria
- Coagulation disorders
- Pregnancy
- Malignancies of other organs unrelated to biliary strictures
- Declined participation
Where it is running
1 location listed.
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine - Shanghai, China, China