Precision Analytic Research Methods in OCD

Recruiting · NCT07011901 · Interventional (participants receive a specific treatment)

View the official record on ClinicalTrials.gov →

Interventions studied

Exposure and Response Prevention

What this trial is about

Psychiatric disorders characterized by compulsivity, such as obsessive-compulsive disorder (OCD), result in considerable functional impairment and many individuals do not respond to gold-standard treatments. Compulsivity has long been thought to occur due to exaggerated habits and reduced goal-directed control, although more recently, this conceptualization of compulsivity as an imbalance of two cognitive systems has been challenged as overly narrow. This study will recruit 100 individuals (50 adults diagnosed with OCD, 50 healthy controls) and leverage the measurement precision offered by theory-driven computational modeling in combination with electroencephalogram (EEG) to go beyond this binary theory of compulsivity, revealing how more complex interactions of neurocognitive subcomponents contribute to compulsivity-information that could ultimately lead to improved treatment personalization and clinical outcomes.

Who can take part

Age range

18 Years to 55 Years

Sex

All (male and female)

Healthy volunteers

Yes - healthy volunteers may be accepted

Phase

Not applicable (e.g. observational or device study)

Study type

Interventional (participants receive a specific treatment)

Inclusion criteria

Participants must be:
between the ages 18-55 years old
English-speaking
right-handed
able to provide consent

Exclusion criteria

Individuals diagnosed with OCD will be excluded if:
they meet diagnostic criteria for certain other psychiatric disorders
are taking psychiatric medication or have received behavioral treatment for OCD within a certain timeframe
if it is unsafe for them to participate in research
Healthy control participants will be excluded if:
they have a current psychiatric disorder
a lifetime history of certain psychiatric disorders
are taking psychiatric medication or have in the past
have a parent or sibling who has been diagnosed with OCD
if it is unsafe for them to participate in research

Where it is running

1 location listed across 1 US state.

Icahn School of Medicine at Mount Sinai - New York, New York, United States

Read the full protocol, contacts and eligibility on ClinicalTrials.gov →