Clinical Application Study of PET/CT for Differential Diagnosis of Non-small Cell Lung Cancer
Recruiting · NCT07026110 · Interventional (participants receive a specific treatment)
View the official record on ClinicalTrials.gov →Interventions studied
[18F]F-RESCA-EPCD6[18F]F-RESCA-RT4[18F]F-RESCA-T4[68Ga]Ga-NOTA-EPCD6[68Ga]Ga-NOTA-RT4[68Ga]Ga-NOTA-T4
What this trial is about
This study aims to explore the efficacy of Trop2, EpCAM-specific PET/CT imaging for noninvasive visualization of Trop2 or EpCAM expression levels in non-small cell lung cancer; and to explore the differences between novel target-specific PET/CT examinations and conventional 18F-FDG PET/CT in the diagnosis and differential diagnosis of solid lung nodules.
Who can take part
Age range
18 Years to 80 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age 18-80 years;
- Imaging studies suspecting non-small cell lung cancer;
- Solid lung nodules (≥8 mm in diameter) diagnosed by chest ct, which are subject to 18F-FDG PET/CT and surgical resection/biopsy of lung nodules according to the NCCN guideline specifications for NSCLC in the 2024 edition;
- Patients or family members agreed to participate in this clinical study and signed an informed consent form.
Exclusion criteria
- Women during pregnancy and lactation;
- Persons with a history of surgery and trauma that significantly affects metabolic distribution and anatomical structure;
- Persons with severe other systemic diseases or known hypersensitivity to humanized monoclonal antibody products;
- Patient is unable to cooperate in completing the PET/CT examination;
- Patient has participated in other clinical studies within the past year that have resulted in radiation exposures in excess of an effective dose of 50 mSv, in addition to the radiation exposures anticipated from participation in this clinical study;
- Patient should not participate in this clinical trial in the opinion of the investigator.
Where it is running
1 location listed.
- Renji Hospital, School of Medicine, Shanghai Jiao Tong University - Shanghai, China