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Conditions › HIV › NCT07029152

Screening for Anal Cancer in Men Who Have Sex With Men Using Pre-Exposure Prophylaxis

Recruiting · NCT07029152 · Interventional (participants receive a specific treatment) · Lead sponsor: Universitair Ziekenhuis Brussel

View the official record on ClinicalTrials.gov →
HIVColorectal cancer

Interventions studied

Anal smearEQ-5D-5L questionnaireHigh Resolution Anoscopy (HRA)Self-administered questionnaire

What this trial is about

This study aims to learn more about anal cancer risk in men who have sex with men (MSM) who are using Pre-Exposure Prophylaxis (PrEP) to prevent HIV. Specifically, we want to check how common High-Grade Squamous Intraepithelial Lesions (HSIL) are in this group, how well anal swabs can screen for these lesions, and how having HSIL affects their quality of life. We'll also test if DNA methylation testing can give us extra information about the lesions. The main questions the study aims to answer are: * How common are HSIL in MSM using PrEP? * How accurate are anal swabs for detecting HSIL in this group? * How does having HSIL affect the quality of life of MSM using PrEP? * Can DNA methylation testing help improve our understanding of HSIL in these individuals? Participants will: * Answer questions about their health and quality of life. * Have an anal smear collected for testing. * Undergo High-Resolution Anoscopy (HRA) to check for HSIL and get a biopsy if deemed necessary.

Who can take part

Age range
35 Years and older
Sex
Male
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)

Inclusion criteria

Exclusion criteria

Where it is running

16 locations listed.

Read the full protocol, contacts and eligibility on ClinicalTrials.gov →

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