Methacholine Challenge Test in School Children With/Without Asthma RISKA
Recruiting · NCT07031102 · Observational (researchers observe without assigning treatment) · Lead sponsor: Helsinki University Central Hospital
View the official record on ClinicalTrials.gov →What this trial is about
The study includes a pre-study telephone interview with healthy controls to assess their eligibility for participation. During the study visit, a background information form and an asthma questionnaire are completed. At the study visit, a methacholine challenge test measuring airway hyperresponsiveness and an exhaled nitric oxide measurement are performed. The effect of medication intensification in asthma patients is further assessed through a telephone interview 1-2 months after the medication adjustment.
Who can take part
Age range
7 Years to 15 Years
Sex
All (male and female)
Healthy volunteers
Yes - healthy volunteers may be accepted
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Healthy Controls
- • Aged 7-15 years, both sexes
- No diagnosis of asthma in childhood
- No inhaled asthma medication during the previous 2 years
- No wheezing or shortness of breath during the previous 2 years
- Written informed consent from the participant and guardian
- Inclusion Criteria: Children with Asthma
- Aged 7-15 years, both sexes
- Physician-diagnosed asthma (ICD-10 codes J45.0/J45.1/J45.9)
- Inhaled corticosteroid treatment for at least 6 months
- Either:
- Well-controlled asthma (c-ACT/ACT score ≥20) and no clinical need to intensify medication, or
- Poorly controlled asthma with physician-confirmed need for intensified asthma medication
Exclusion criteria
- • Premature birth before 32 gestational weeks
- Other chronic cardiopulmonary or neurological conditions affecting airways (excluding asthma)
- Severe underlying illness such as malignancy
- Beta-blocker medication
- Active immunological disease
Where it is running
1 location listed.
- HUS Skin and Allergy Hospital - Helsinki, Finland