UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF
Recruiting · NCT07054489 · Interventional (participants receive a specific treatment) · Lead sponsor: David Lanfear
View the official record on ClinicalTrials.gov →Interventions studied
Beta blocker
What this trial is about
This study will use polygenic scores, a tool which describes differences in genetics, to examine effectiveness of beta blocker medication in heart failure patients with ejection fraction of 41-50 percent. The study will also assess beta blockers' effect on the changes in left ventricular end-systolic volume index by MRI.
Who can take part
Age range
18 Years to 89 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age 18-89 years
- Ejection Fraction (EF) \>40% and =\<50% by any modality within 1 year (must be most recent)
- Clinical diagnosis of HF within 1 year, evidenced by any one: Hospital discharge with primary or secondary HF diagnosis, ER discharge with primary diagnosis of HF, ambulatory diagnostic code for HF and diuretic use, BNP\>35 ng/L or NTproBNP \>125 ng/L at any time
- Expected ability to fully participate in study (can tolerate study processes, no long travel)
Exclusion criteria
- Unable to provide informed consent
- Previous documented EF =\< 35%
- Currently on BB =\>25% target dose
- Uncontrolled hypertension (systolic BP \> 180 at enrollment)
- Has contraindications to all BB or intolerance to metoprolol
- Systolic BP \< 100 or heart rate \<70
- Current cancer requiring active treatment
- Heart transplant or LVAD or expected in the next year
- Life expectancy \< 1 year for any reason
- Dialysis dependence or ESRD
- MI/ PCI or other cardiac surgery within 90 days prior to enrollment or planned in the future
- Absolute indication for BB other than heart failure (e.g. tachyarrhythmia required BB for rate control, angina)
- If PI decides for any reason participation in trial is not in best interest of the patient
- Has a contraindication to completing MRI procedures
Where it is running
1 location listed across 1 US state.
- Henry Ford Health - Detroit, Michigan, United States