A Study to Evaluate Splenectomy on Debridement for Acute Necrotizing Pancreatitis With Pancreatic Sinistral Portal Hypertension
Recruiting · NCT07080697 · Interventional (participants receive a specific treatment) · Lead sponsor: Zhejiang University
View the official record on ClinicalTrials.gov →Interventions studied
ControlSplenectomy
What this trial is about
This study is a prospective, single-center, randomized controlled trial focusing on patients with acute necrotizing pancreatitis (ANP) complicated by pancreatic sinistral portal hypertension (PSPH). The study aims to study the impact of total splenectomy on the debridement efficacy, perioperative recovery, and prognosis of patients with ANP complicated by PSPH.
Who can take part
Age range
18 Years to 75 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age between 18 and 75 years.
- Acute necrotic pancreatitis complicated by pancreatic sinistral portal hypertension.
- Patients undergoing open debridement for infected pancreatic necrosis
Exclusion criteria
- Patients with pre-existing heart, lung, liver, kidney, or other organ failure prior to acute pancreatitis (AP).
- Patients with pre-existing conditions such as cirrhosis that may lead to portal hypertension prior to AP.
- Patients with pre-existing hematological diseases prior to AP.
- Patients undergoing laparoscopic or nephroscopic debridement.
Where it is running
1 location listed.
- First Affiliated Hospital, Zhejiang University School of Medicine - Hangzhou, Zhejiang, China