Effect of Vitamin D3 Supplementation on Cardiac Autonomic Nerve Function in Male Parkinson's Disease Patients With Hypovitaminosis D
Recruiting · NCT07084597 · Interventional (participants receive a specific treatment) · Lead sponsor: Bangladesh Medical University
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
The goal of this clinical trial is to see the effect of vitamin D3 supplementation on cardiac autonomic nerve function in male Parkinson's disease patients with hypovitaminosis D Main questions it aims to answer are: 1. Does vitamin D improves heart rate variability(HRV) in male Parkinson's disease patients ? 2. Does vitamin D improves cardiac autonomic nerve function in male Parkinson's disease patients ? It is a self control trial. Vitamin D3 deficient Parkinson's disease participants will a. undergo through baseline HRV test b. Then they will take vitamin D3 capsule 50000 IU once in a week for 8 consecutive weeks c. Then after intervention with vitamin D supplementation post interventional HRV will be done. Researcher will compare pre intervention(pre test) and post intervention(post test) value of HRV
Who can take part
Inclusion criteria
- Male patients with of Parkinson's disease diagnosed by neurologist with unilateral or bilateral involvement and mild to moderate disability according to Hoehn and Yahr (H-Y) scale (I-III)
- Age: 51-70 years
- BMI: 18.5-24.9 kg/m2
- Vitamin D3 deficient or insufficient
- On Levodopa medication
Exclusion criteria
- Patients with a history of drug abuse including alcoholism.
- Patients on following drugs will be excluded-
- Antioxidant vitamin supplements
- Lipid lowering medications
- Antihypertensive drug
- Anti-arrhythmic drug
- Sedatives
- All patients with the history of or clinical manifestation of currently suffering from following diseases \& condition will be excluded
- Severe Cardiovascular disorders
- Severe neurological disorders
- Severe Respiratory disorders
- Severe Renal insufficiency (S. Creatinine \> 1.5 mg/dl, Acute or chronic kidney disease)
- Severe Endocrine disease
- Severe Arthritis
- Severe Liver diseases
- Severe Neoplastic disease
- Severe Psychiatric disorder
- Current use of iron, zinc, calcium, magnesium and multivitamin supplementation
- Already performing yoga or breathing exercise
- Hypercalcemia
Where it is running
1 location listed.
- Bangladesh Medical University - Dhaka, Shahbag, Bangladesh