Efficacy of Gamma Auditory Stimulation for Cognitive Decline in Older Adults (Study 1)
Recruiting · NCT07087951 · Interventional (participants receive a specific treatment) · Lead sponsor: Chang Gung Memorial Hospital
View the official record on ClinicalTrials.gov →Interventions studied
Gamma auditory stimulation device (active setting)Gamma auditory stimulation device (sham setting)
What this trial is about
Animal studies have shown that 40 Hz auditory stimulation alone can improve spatial memory and reduce Aβ deposition. However, human studies using 40 Hz auditory stimulation alone remain limited. Therefore, this study will use a randomized, double-blind, placebo-controlled design to investigate the effects of 40 Hz auditory stimulation on cognitive function, EEG activity, sleep quality, and quality of life in older adults with mild cognitive impairment (MCI) or mild dementia.
Who can take part
Age range
60 Years and older
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Age over 60 years old.
- MMSE≤ 24
- CDR scores of 0.5 and 1
- Voluntary to sign the Informed Consent Form.
Exclusion criteria
- Diagnosis of other psychiatric or neurological disorders
- Drug or alcohol addictions.
- Serious heart, liver or kidney disorders, and visual, auditory or motor impairments interfering with neuropsychological tests.
- History of clinical stroke, major depressive disorder or dysthymic disorder according to the DSM-5.
Where it is running
1 location listed.
- Chang Gung University - Taoyuan, Guishan, Taiwan