Definitive Radiation Therapy for Inoperable Breast Cancer
Recruiting · NCT07122713 · Interventional (participants receive a specific treatment)
View the official record on ClinicalTrials.gov →Interventions studied
Whole breast radiation with simultaneous integrated boost (WB-SIB) to primary breast tumorWhole breast radiation with simultaneous integrated boost (WB-SIB) to primary breast tumor and ipsilateral axillary lymph nodes
What this trial is about
The purpose of this study is to find out if adding radiation therapy to routine medications for breast cancer helps in reducing and preventing the cancer from getting worse. Patients with a locally advanced breast cancer who cannot, or do not want to, undergo surgery are eligible to participate. Participation in this study does not prevent you from undergoing surgery in the future.
Who can take part
Age range
18 Years and older
Sex
Female
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not applicable (e.g. observational or device study)
Study type
Interventional (participants receive a specific treatment)
Inclusion criteria
- Biopsy proven invasive carcinoma of the breast, either lobular, ductal and/or no special type
- T1-T4, N0-2, M0-1 invasive breast carcinoma by radiological or clinical criteria
- Cancer is deemed unresectable, or the patient is a poor surgical candidate as determined following evaluation by a surgeon, or patient declines surgery.
- Life expectancy \> 6 months
- Negative pregnancy test at the time of start of treatment in any female of reproductive age
Exclusion criteria
- Concurrent systemic therapy (except for endocrine therapy, HER2-targeted therapy, or immunotherapy which are permitted)
- Prior radiation to ipsilateral breast or regional nodes
- Inability to receive study treatment planning and treatment secondary to body habitus
Where it is running
1 location listed across 1 US state.
- Stony Brook University Cancer Center - Stony Brook, New York, United States