DESTINY-PANTUMOUR04
Recruiting · NCT07124000 · Observational (researchers observe without assigning treatment) · Lead sponsor: AstraZeneca
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
This study will evaluate the effectiveness of T-DXd in patients with HER2-positive (IHC 3+) locally advanced, unresectable, or metastatic solid tumors who have received prior systemic treatment for metastatic or advanced disease and have no satisfactory alternative treatment options in a real-world setting in the US
Who can take part
Age range
18 Years to 130 Years
Sex
All (male and female)
Healthy volunteers
No - a diagnosis or condition is required
Phase
Not specified
Study type
Observational (researchers observe without assigning treatment)
Inclusion criteria
- Adults aged ≥18 years
- Patients with locally advanced, unresectable, or metastatic HER2-positive (IHC 3+) solid tumors who have received prior systemic treatment for metastatic or advanced disease and have no satisfactory alternative treatment options as determined by the Investigator (see Exclusion Criterion 1 for excluded solid tumors);
- A clinician decision has been made for treatment with T-DXd in accordance with the FDA label;
- HER2-positive (IHC 3+) by local testing prior to study enrolment at the time of signed and dated informed consent;
- Patients who are willing and able to provide a signed and dated informed consent.
Exclusion criteria
- Primary diagnosis of adenocarcinoma of the breast, adenocarcinoma of the colon or rectum, NSCLC, adenocarcinoma of the gastric body or gastroesophageal junction or hematological malignancies;
- Prior T-DXd therapy;
- Patients without a baseline assessment of tumor burden undertaken prior to initiating T-DXd.
- Patient is participating in a clinical trial at time of enrolment
Where it is running
36 locations listed across 13 US states.
- Research Site - Birmingham, Alabama, United States
- Research Site - Birmingham, Alabama, United States
- Research Site - Bullhead City, Arizona, United States
- Research Site - Bullhead City, Arizona, United States
- Research Site - Casa Grande, Arizona, United States
- Research Site - Casa Grande, Arizona, United States
- Research Site - San Diego, California, United States
- Research Site - San Diego, California, United States
- Research Site - Boulder, Colorado, United States
- Research Site - Boulder, Colorado, United States
- Research Site - Coral Springs, Florida, United States
- Research Site - Coral Springs, Florida, United States
- Research Site - St. Petersburg, Florida, United States
- Research Site - St. Petersburg, Florida, United States
- Research Site - West Palm Beach, Florida, United States
- Research Site - West Palm Beach, Florida, United States
- Research Site - Decatur, Illinois, United States
- Research Site - Decatur, Illinois, United States
- Research Site - Topeka, Kansas, United States
- Research Site - Topeka, Kansas, United States
- Research Site - Farmington, New Mexico, United States
- Research Site - Farmington, New Mexico, United States
- Research Site - Durham, North Carolina, United States
- Research Site - Durham, North Carolina, United States
- Research Site - Wilson, North Carolina, United States
- Research Site - Wilson, North Carolina, United States
- Research Site - Canton, Ohio, United States
- Research Site - Canton, Ohio, United States
- Research Site - Maumee, Ohio, United States
- Research Site - Maumee, Ohio, United States
- Research Site - Philadelphia, Pennsylvania, United States
- Research Site - Philadelphia, Pennsylvania, United States
- Research Site - Nashville, Tennessee, United States
- Research Site - Nashville, Tennessee, United States
- Research Site - Dallas, Texas, United States
- Research Site - Dallas, Texas, United States