Aromatherapy Essential Oils to Manage Anxiety and Nausea in Cancer Patients Receiving Infusion in the Ambulatory Setting
Recruiting · NCT07126301 · Interventional (participants receive a specific treatment) · Lead sponsor: City of Hope Medical Center
View the official record on ClinicalTrials.gov →Interventions studied
What this trial is about
This clinical trial tests how well aromatherapy essential oils work to manage anxiety and nausea in cancer patients receiving infusions in the ambulatory setting. Current drugs that are given for nausea may cause constipation and fatigue. Therefore, there is interest in exploring complementary therapies, like aromatherapy, that do not carry the same side effects. Using aromatherapy essential oils such as ginger, peppermint, and lavender, may help reduce nausea and anxiety. Some studies have shown significant reductions in nausea and anxiety among cancer patients using these oils, while other studies have had mixed results. Ginger and peppermint oils, in particular, have been associated with helping reduce nausea during chemotherapy, while lavender has shown potential benefits for anxiety. Jojoba oil will be used as a placebo for this research study. Jojoba oil is extracted from the seeds of a jojoba plant, which is a green shrub that is found in the southwestern United States). Jojoba oil is an oil which has no color or smell. Aromatherapy essential oils used through a personal inhalation device during chemotherapy may better manage anxiety and nausea in cancer patients receiving infusions in the ambulatory setting.
Who can take part
Inclusion criteria
- Patients must have the ability to understand and sign a written informed consent document, and be willing to follow protocol requirements
- Ability to read and understand English for patient reported outcomes
- Age \>= 18 years
- Eastern Cooperative Oncology Group (ECOG) performance status =\< 2
- Willingness to comply with all study interventions of essential oil aromatherapy
- Have been on a moderate- to high-risk emetogenic chemotherapy regimen as defined by the National Comprehensive Cancer Network (NCCN) for at least 1 cycle of therapy
- At least 2 remaining infusion appointments on a moderate- to high-risk emetogenic chemotherapy regimen as defined by the NCCN
- Have nausea defined as \> 3/10 with last chemotherapy infusion based on screening symptom questionnaire
- The study is open to all participants regardless of gender, race, or ethnicity
Exclusion criteria
- Self-reported aversion or sensitivity to lavender oil, peppermint oil, ginger oil, jojoba oil
- Uncontrolled respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD)
- Mental incapacitation (ex. stroke, brain metastasis etc.) that would cause inability to follow directions, in the opinion of the investigators
- Ongoing uncontrolled active psychiatric condition that would interfere in the conduct of the study (e.g., mood disorders, anxiety, psychosis disorders, or substance use)
- Self-reported abnormal smelling abilities (for ex: ongoing sinus infections, long covid, etc.)
- Aromatherapy use in the last 30 days
Where it is running
2 locations listed across 1 US state.
- City of Hope Medical Center - Duarte, California, United States
- City of Hope at Irvine Lennar - Irvine, California, United States